5422-34-4

Basic information

• Product Name: N-(2-HYDROXYETHYL)LACTAMIDE
• Synonyms: 2-hydroxy-n-(2-hydroxyethyl)-propanamid;2-Hydroxy-N-(2-hydroxyethyl)propanamide;2-hydroxy-N-(2-hydroxy-ethyl)-propionamide;Incromectant LMEA;Lactamide MEA;Lactamide, N-(2-hydroxyethyl)-;lactamidemea;Lactic acid monoethanolamide
• CAS NO: 5422-34-4
• Molecular Formula: C₅H₁₁NO₃
• Molecular Weight: 133.15
• EINECS: 226-546-1
• Mol File: 5422-34-4.mol

Chemical Properties

• Boiling Point: 380.3 °C at 760 mmHg
• Flash Point: 183.8 °C
• Appearance: /
• Density: 1,2 g/cm3
• Vapor Pressure: 2.4E-07mmHg at 25°C
• Refractive Index: 1.4820 to 1.4870
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 13.34±0.20(Predicted)
• CAS DataBase Reference: N-(2-HYDROXYETHYL)LACTAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-HYDROXYETHYL)LACTAMIDE(5422-34-4)
• EPA Substance Registry System: N-(2-HYDROXYETHYL)LACTAMIDE(5422-34-4)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• RTECS: OD2400000
• Hazardous Substances Data: 5422-34-4(Hazardous Substances Data)

Usage

Uses

Used in Personal Care Industry:
N-(2-HYDROXYETHYL)LACTAMIDE is used as a surfactant for enhancing the foaming and cleansing properties of personal care products. Its thickening and stabilizing properties also contribute to the improved texture and consistency of these products, providing a better user experience.
Used in Industrial Applications:
In the industrial sector, N-(2-HYDROXYETHYL)LACTAMIDE is utilized as a thickener and stabilizer in various formulations, such as paints, coatings, and adhesives. Its ability to improve the viscosity and stability of these products leads to better performance and longer shelf life.
Used in Pharmaceutical Industry:
N-(2-HYDROXYETHYL)LACTAMIDE is used as an excipient in the pharmaceutical industry, where it serves as a stabilizing agent for drug formulations. Its surfactant properties also aid in the solubilization and dispersion of active pharmaceutical ingredients, enhancing the overall efficacy of the medication.
Used in Cosmetics Industry:
In the cosmetics industry, N-(2-HYDROXYETHYL)LACTAMIDE is employed as a foam booster and stabilizer, particularly in products that require a rich, luxurious lather, such as shampoos and body washes. Its thickening properties also contribute to the desired consistency and texture of these products, making them more appealing to consumers.

Flammability and Explosibility

Nonflammable

InChI:InChI=1/C5H11NO3/c1-4(8)5(9)6-2-3-7/h4,7-8H,2-3H2,1H3,(H,6,9)

Upstream product

• 97-64-3 ethyl 2-hydroxypropionate 
• 141-43-5 ethanolamine 
• 547-64-8 methyl lactate 

Relevant articles and documents

FORUMLATIONS

This invention relates to the use of lactamide compounds of formula (I): CH3CH(OH)C(=O)NR1R2, where R1 and R2 are each independently hydrogen; or C1-6 alkyl, C2-6 alkenyl or C3-6 cycloalkyl, each of which is optionally substituted by up to three substituents independently selected from phenyl, hydroxy, C1-5 alkoxy, morpholinyl and NR3R4 where R3 and R4 are each independently C1-3 alkyl; or phenyl optionally substituted by up to three substituents independently selected from C1-3 alkyl; or R1 and R2 together with the nitrogen atom to which they are attached form a morpholinyl, pyrrolidinyl, piperidinyl or azepanyl ring, each of which is optionally substituted by up to three substituents independently selected from C1-3 alkyl, in formulations to reduce the toxicity associated with other formulation components; to the use of certain lactamide compounds as solvents, especially in formulations, particularly in agrochemical formulations and in environmentally friendly formulations; to novel lactamide compounds; and to processes for preparing lactamide compounds.

Reactions of Hydroxy Carboxylic Acid Amides and Their O-Trimethylsilyl Derivatives with Chloro(chloromethyl)-dimethylsilane. Synthesis of 1-Oxa-4-aza-2-sila-and 1-Oxa-4-aza-2,6-disilacyclohexanes

A general strategy has been developed for the synthesis of 1-oxa-4-aza-2-silacyclohexanes, 1-oxa-4-aza-2-silacyclohexan-5-ones, and 4-acyl-1-oxa-4-aza-2-silacyclohexanes from carboxylic acid amides containing a hydroxy group in the acid and/or amide moiety via two routes. The first of these includes transformation of N-monosubstituted carboxamides into corresponding O-trimethylsilyl derivatives which react with chloro(chloromethyl)dimethylsilane in the presence of a base to form unstable N-chlorodimethylsilyl-methyl amide derivatives with a five-coordinate silicon atom. Thermal decomposition of the latter during fractionation yields the target silicon-containing heterocycles with an OSiCH2N fragment. The second route consists of direct treatment of N-monosubstituted carboxamides with a mixture of hexamethyldisilazane and chloro(chloromethyl)dimethylsilane, which results in formation of 1-oxa-4-aza-2-silacyclohexan-5-ones and 4-acyl-1-oxa-4-aza-2-silacyclohexanes in high yields, thus excluding preliminary O-silylation of the starting hydroxy amides. One-pot reactions of N-unsubstituted carboxylic acid amides with a hexamethyldisilazane-chloro(chloromethyl)dimethylsilane mixture, followed by hydrolysis, yield 4-acyl-1-oxa-4-aza-2,6-disilacyclohexanes.

Skin-care agents containing hydroxyalkyl carboxamides and process

Skin-care, skin-protection, and skin-cleaning agent compositions containing at least one hydroxyalkyl carboxamide as a skin-moisturizing agent, as well as a process for protecting the skin utilizing this composition.