54251-80-8Relevant articles and documents
PROCESS OF MAKING CFTR MODULATORS
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Paragraph 0418-0420; 0756; 0757, (2021/02/19)
The disclosure provides processes for synthesizing Compound I, and pharmaceutically acceptable salts thereof.
Iron-Catalyzed Triazole-Enabled C-H Activation with Bicyclopropylidenes
Mo, Jiayu,Messinis, Antonis M.,Oliveira, Joa? C. A.,Demeshko, Serhiy,Meyer, Franc,Ackermann, Lutz
, p. 1053 - 1064 (2021/01/26)
C-H/C-C functionalizations with oxymethylated bicyclopropylidenes were accomplished with an iron catalyst under external oxidant-free conditions. The combination of the unique reactivity of bicyclopropylidenes with a robust iron(II) catalyst enabled C-C c
Copper-mediated tandem ring-opening/cyclization reactions of cyclopropanols with aryldiazonium salts: Synthesis of: N -arylpyrazoles
Liu, Jidan,Xu, Erjie,Jiang, Jinyuan,Huang, Zeng,Zheng, Liyao,Liu, Zhao-Qing
supporting information, p. 2202 - 2205 (2020/02/26)
A general method for the synthesis of structurally diverse N-arylpyrazoles from readily available cyclopropanols and aryldiazonium salts is disclosed. The reaction was conducted at room temperature within minutes with a broad substrate scope and excellent regioselectivity.
