60629-95-0

Usage

Physical state

Clear, colorless liquid

Solubility

Insoluble in water

Usage

Primarily used in organic synthesis and pharmaceutical research

Building block

For creating more complex molecules

Reactivity

High reactivity due to the presence of the bromine atom and the strained cyclopropane ring

Intermediate

Used in the production of various agrochemicals and pharmaceuticals

Unique structure

Valuable tool in the field of chemical and pharmaceutical research

Upstream product

• 60629-94-9 Silber-1,1'-bicyclopropyl-1-carboxylat 
• 54251-80-8 hydroxy-1 cyclopropyl-1 cyclopropane 

Downstream Products

• 27567-82-4 bicyclopropylidene 
• 60629-92-7 1-cyclopropylcyclopropanecarboxylic acid 
• 1236076-70-2 2-([1,1'-bi(cyclopropan)]-1-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 
• 1391838-13-3 [3-(1,1'-bicyclopropyl-1-yl)phenyl]trimethylsilane 
• 1391838-16-6 1-(1,1'-bicyclopropyl-1-yl)-2,3-bis(methoxymethyl)benzene 
• 1391837-72-1 (1-cyclopropylcyclopropyl)ethyne 
• 151964-06-6 1,1'-Bicyclopropylidene-2-carboxylic acid 

Relevant academic research and scientific papers

Iron-Catalyzed Triazole-Enabled C-H Activation with Bicyclopropylidenes

C-H/C-C functionalizations with oxymethylated bicyclopropylidenes were accomplished with an iron catalyst under external oxidant-free conditions. The combination of the unique reactivity of bicyclopropylidenes with a robust iron(II) catalyst enabled C-C c

PROCESS OF MAKING CFTR MODULATORS

The disclosure provides processes for synthesizing Compound I, and pharmaceutically acceptable salts thereof.

MODULATOR OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR, PHARMACEUTICAL COMPOSITIONS, METHODS OF TREATMENT, AND PROCESS FOR MAKING THE MODULATOR

Compounds of Formula (I) pharmaceutically acceptable salts thereof, deuterated derivatives of any of the foregoing, and metabolites of any of the foregoing are disclosed. Pharmaceutical compositions comprising the same, methods of treating cystic fibrosis using the same, and methods for making the same are also disclosed. Also disclosed are solid state forms of Compound 1 and salts and solvates thereof.

OLIGOMETHYLENATION OF BICYCLOPROPYLIDENE BY DIAZOMETHANE IN THE PRESENCE OF PALLADIUM(II) ACETATE

Oligomethylenation, leading to the inclusion of three or four equivalents of methylene in the molecule, takes place during the reaction of bicyclopropylidene with diazomethane in the presence of palladium(II) acetate.