54256-45-0

Basic information

• Product Name: 1-OCTYLPIPERAZINE
• Synonyms: RARECHEM AH CK 0147;1-OCTYLPIPERAZINE;1-N-OCTYLPIPERAZINE;1-(1-OCTYL)-PIPERAZINE;Octylpiperazine;1-(n-Octyl)piperazine 97%;1-(1-OCTYL)-PIPERAZINE 99%;1-Octylpiperazine ,97%
• CAS NO: 54256-45-0
• Molecular Formula: C₁₂H₂₆N₂
• Molecular Weight: 198.35
• Product Categories: Building Blocks;Heterocyclic Building Blocks;Piperazines
• Mol File: 54256-45-0.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 240-241 °C(lit.)
• Flash Point: >115 °F
• Appearance: Colorless/Liquid
• Density: 0.836 g/mL at 25 °C(lit.)
• Refractive Index: n20/D 1.4670(lit.)
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• CAS DataBase Reference: 1-OCTYLPIPERAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-OCTYLPIPERAZINE(54256-45-0)
• EPA Substance Registry System: 1-OCTYLPIPERAZINE(54256-45-0)

Safety Data

• Hazard Codes: Xi
• Statements: 10-36/37/38
• Safety Statements: 26
• RIDADR: UN 1993 3/PG 3
• WGK Germany: 3
• HazardClass: 3
• Hazardous Substances Data: 54256-45-0(Hazardous Substances Data)

Usage

General Description

1-Octylpiperazine, also known as OPZ, is a chemical compound with the molecular formula C12H24N2. It is a piperazine derivative, a class of organic compounds that are widely used in the pharmaceutical and agricultural industries. 1-Octylpiperazine is mainly used as an intermediate in the production of various pharmaceuticals, agrochemicals, and specialty chemicals. It is also utilized as a corrosion inhibitor and a building block for the synthesis of novel compounds. Additionally, it has been studied for its potential use in the treatment of neurological disorders and various other medical applications. 1-OCTYLPIPERAZINE has a range of industrial and research applications due to its unique chemical structure and properties.

Upstream product

• 110-85-0 piperazine 
• 111-87-5 octanol 
• 111-83-1 1-bromo-octane 
• 629-27-6 1-Iodooctane 
• 111-85-3 n-chlorooctane 

Downstream Products

• 353247-85-5 4-(4-octyllpiperazin-1-yl)benzaldehyde 

Relevant articles and documents

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Alkylated Piperazines and Piperazine-Azole Hybrids as Antifungal Agents

The extensive use of fluconazole (FLC) and other azole drugs has caused the emergence and rise of azole-resistant fungi. The fungistatic nature of FLC in combination with toxicity concerns have resulted in an increased demand for new azole antifungal agents. Herein, we report the synthesis and antifungal activity of novel alkylated piperazines and alkylated piperazine-azole hybrids, their time-kill studies, their hemolytic activity against murine erythrocytes, as well as their cytotoxicity against mammalian cells. Many of these molecules exhibited broad-spectrum activity against all tested fungal strains, with excellent minimum inhibitory concentration (MIC) values against non-albicans Candida and Aspergillus strains. The most promising compounds were found to be less hemolytic than the FDA-approved antifungal agent voriconazole (VOR). Finally, we demonstrate that the synthetic alkylated piperazine-azole hybrids do not function by fungal membrane disruption, but instead by disruption of the ergosterol biosynthetic pathway via inhibition of the 14α-demethylase enzyme present in fungal cells.

CARBODITHIOATES WITH SPERMICIDAL ACTIVITY AND PROCESS FOR PREPARATION THEREOF

The present invention relates to the synthesis and biological evaluation of compound of formula I as spermicidal agents, and its pharmaceutically acceptable acid salt thereof. The invention provides bis(4- substituted-1-piperazinylthiocarbonyl) disulfide (when n = 0) and alkane-1,n-diylbis(4-substituted piperazine-1-carbodithioate) (when n = 0, 1, 2 or 3) as shown in figure 1 of the accompanying drawing. These compounds are found to be useful for spermicidal activity.