5426-17-5Relevant articles and documents
Regiodivergent Conversion of Alkenes to Branched or Linear Alkylpyridines
Kim, Minseok,Shin, Sanghoon,Koo, Yejin,Jung, Sungwoo,Hong, Sungwoo
supporting information, p. 708 - 713 (2022/01/20)
Herein we report a practical protocol for the visible-light-induced regiodivergent radical hydropyridylation of unactivated alkenes using pyridinium salts. This approach provides a unified synthetic platform to control the regioselectivity of the synthesis of linear or branched C4-alkylated pyridines. A remarkable selectivity switch from the anti-Markovnikov to the Markovnikov product can be achieved by the addition of tetrabutylammonium bromide. The versatility of this protocol is further demonstrated based on the late-stage functionalization in pharmaceuticals.
Intramolecular aromatic alkylation. 28. Synthesis and pharmacological testing of homologized and hydroxylated 3,4-dihydro-1'-methylspiro[naphthalin-1(2H),4'-piperidine
Reimann,Speckbacher,Schuenemann
, p. 35 - 39 (2007/10/02)
The compounds 4, 8, and 10, prepared by standard methods, are converted to the phenylpyridylakanes 9; their methoiodides 11 are reduced to yield the tetrahydropyridines 12. Whereas the cyclisation of 12a gives the isomers 1f and 1g, 12b furnishes only the
