54265-98-4Relevant academic research and scientific papers
Visible-Light-Promoted Synthesis of α-CF2H-Substituted Ketones by Radical Difluoromethylation of Enol Acetates
Cheng, Li,Dong, Bingbing,Feng, Zengqiang,Li, Yunpu,Wang, Zechao,Wu, Junliang,Zhu, Baoxiang
, p. 508 - 513 (2021)
An efficient and novel visible-light-promoted radical difluoromethylation of enol acetates for the synthesis of α-CF2H-substituted ketones has been described. Upon irradiation under blue LED with catalytic amounts of fac-Ir(ppy)3, this photocatalytic procedure employs difluoromethyltriphenylphosphonium bromide as a radical precursor. Various α-CF2H-substituted ketones are successfully created via designed systems based on the SET process. The methodology has also provided an operationally simple process with broad functional group compatibility.
