54276-69-6

Upstream product

• 612-25-9 2-Nitrobenzyl alcohol 
• 7693-46-1 4-Nitrophenyl chloroformate 

Downstream Products

• 473910-23-5 [9-((2R,4S,5R)-4-Hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl]-carbamic acid 2-nitro-benzyl ester 
• 473910-24-6 [1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-2-oxo-1,2-dihydro-pyrimidin-4-yl]-carbamic acid 2-nitro-benzyl ester 
• 473910-27-9 C₂₅H₂₃N₇O₁₀ 
• 473910-25-7 [6-Oxo-9-((2R,3aS,9aR)-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl)-6,9-dihydro-1H-purin-2-yl]-carbamic acid 2-nitro-benzyl ester 
• 473910-26-8 C₃₇H₄₉N₇O₁₁Si₂ 
• 473910-28-0 C₄₆H₄₁N₇O₁₂ 
• 1009315-18-7 2-nitrobenzyl 2-(1H-indol-3-yl)ethylcarbamate 
• 1422962-86-4 C₃₃H₄₆N₈O₁₂ 
• 1470259-71-2 C₁₈H₂₂N₂O₆ 
• 1470259-73-4 C₁₉H₂₄N₂O₆ 
• 1470259-75-6 C₂₀H₂₆N₂O₆ 
• 1470259-77-8 C₂₁H₂₈N₂O₆ 
• 1470259-79-0 C₂₂H₃₀N₂O₆ 
• 1470259-81-4 C₂₃H₃₂N₂O₆ 

Relevant academic research and scientific papers

Synthesis of photocaged diamines and their application in photoinduced self-assembly

The photochemical cleavage of covalent bonds is an important strategy in protection group chemistry, as well as for the triggering of chemical events posterior to the application of the physicochemical stimulus. Photocages allow the arresting and traceles

External-Radiation-Induced Local Hydroxylation Enables Remote Release of Functional Molecules in Tumors

Radiation-induced cleavage for controlled release in vivo is yet to be established. We demonstrate the use of 3,5-dihydroxybenzyl carbamate (DHBC) as a masking group that is selectively and efficiently removed by external radiation in vitro and in vivo. D

Photoinduced depolymerization of poly(olefin sulfone)s possessing photobase generator side-chains: Effect of spacer-chain length

Photoinduced depolymerization of poly(olefin sulfone)s possessing photobase generators in the side-chain was investigated. Irradiation with UV light generated base on the side-chains and induced depolymerization based on proton abstraction on the main-cha

Photoresponsive dendronized copolymers of styrene and maleic anhydride pendant with poly(amidoamine) dendrons as side groups

A series of photoresponsive dendronized polymers PGn-NB (n = 1, 2, 3) were synthesized by attaching o-nitrobenzyl alcohol-terminated amidoamine dendrons (G1-G3) to the alternating styrene and maleic anhydride copolymer (PSt-alt-PMAh). The structures and the molecular weights of the obtained polymers were characterized by 1H NMR and FTIR measurements. It is found that the coverage degrees of the dendrons are 74%, 42%, and 26%, respectively, indicating that the numbers of the appended dendrons decrease in the order of G1 > G2 > G3 due to the steric hindrance of higher generation dendrons with more branches. The photocleavable behavior of G1-G3 was detected by UV-vis and 1H NMR measurements. As a result, G2 showed a faster cleavage rate compared to G1 and G3. The critical aggregation concentration (CAC) of PGn-NB (n = 1, 2, 3), measured by using pyrene as a fluorescence probe, were 0.05 mg/mL (PG1-NB), 0.01 mg/mL (PG2-NB), and 0.03 mg/mL (PG3-NB), which displayed that the structure of PG2-NB was in favor of forming aggregates at lower concentrations. Light scattering study indicated that both the apparent molecular weight and the chain density of the aggregates formed by PG2-NB decreased with the irradiation time. Atomic force microscope (AFM) measurements also showed that the size of the aggregates increased dramatically from 15 to 70 nm before and after UV irradiation, evidencing that the UV light induced structure change. Nile Reds, as the guest molecules, were loaded in the aggregates from PG2-NB, and the release profiles upon UV stimulus were monitored by the fluorescence spectroscopy.

2,4-Bis(hydroxymethyl)aniline as a building block for oligomers with self-eliminating and multiple release properties

(Chemical Equation Presented) Linear self-eliminating (LSE) systems are oligomers of branched self-eliminating linkers that disassemble upon a single triggering event under complete degradation of the linear backbone, accompanied by the release of side-ch

Photolabile groups for exocyclic amino and O6/N-1 lactam protection in oligonucleotide synthesis

The use of o-nitrobenzyloxycarbonyl (nCbz) for direct protection of exocyclic amino function of nucleosides viz. adenosine, cytidine and deoxyguanosine using o-nitrobenzyl-p-nitrophenyl carbonate as a reagent and O6-derivatization of deoxyguanosine with o-nitrobenzyl (nBzl) using o-nitrobenzyldiazomethane as a reagent is being reported. Both these protected groups could be cleaved by irradiation at 354nm to yield valuable building blocks for oligonucleotide synthesis.