54288-06-1Relevant academic research and scientific papers
Efficient iron-catalyzed direct β-alkylation of secondary alcohols with primary alcohols
Yang, Jian,Liu, Xin,Meng, Da-Li,Chen, Hong-Yan,Zong, Zhi-Hui,Feng, Ting-Ting,Sun, Kai
supporting information; experimental part, p. 328 - 334 (2012/04/04)
The efficient iron-catalyzed direct β-alkylation of secondary alcohols with primary alcohols is described. In the presence of the commercially available iron catalyst (ferrocenecarboxaldehyde, 1b) and a catalytic amount of base, the reactions give β-alkylated higher alcohols in high yields in the absence of any sacrificial agents (hydrogen acceptors or hydrogen donors) and nitrogen or phosphorus ligands. For the first time, iron is employed as an inexpensive and environmentally benign alternative with high atom efficiency to noble metal-based catalysts in this type of reaction. Copyright
Alkylation of aldehydes with trialkylboranes in water
Hirano, Koji,Yorimitsu, Hideki,Oshima, Koichiro
, p. 1543 - 1546 (2007/10/03)
Water enables the alkylation of aldehydes with trialkylboranes under nickel catalysis without the addition of a base. Trialkylboranes prepared from borane-dimethyl sulfide and terminal olefins via hydroboration as well as commercially available trialkylboranes could be employed for the reaction. The reaction would proceed via η2-coordinated nickel complexes with aldehydes as the key intermediates.
Nickel-catalyzed alkylation of aldehydes with trialkylboranes
Hirano, Koji,Yorimitsu, Hideki,Oshima, Koichiro
, p. 4689 - 4691 (2007/10/03)
(Chemical Equation Presented) Nickel-catalyzed alkylation of aldehydes with trialkylboranes proceeds smoothly in the presence of a catalytic amount of 5-allyl-1,2,3,4,5-pentamethyl-1,3-cyclopentadiene or an excess of cesium carbonate to afford the corresponding secondary alcohols.
