54291-84-8Relevant academic research and scientific papers
Transition-metal-free intramolecular N-arylations
Thome, Isabelle,Bolm, Carsten
supporting information; experimental part, p. 1892 - 1895 (2012/05/20)
N-Substituted phenoxazines and related aza analogs have been prepared from N-acetylated aryloxy anilides by transition-metal-free, base-catalyzed cyclization reactions. In the presence of a mixture of 10 mol % of N,N′-dimethylethylenediamine (DMEDA) and 2 equiv of K2CO 3 in toluene at 135 °C the products are obtained in high yields.
4-Hydroxy-2'-nitrodiphenyl ether analogues as novel tyrosinase inhibitors
Sapkota, Kiran,Lee, Eunyoung,Yang, Jae-Ho,Kwon, Youngjoo,Choi, Jongwon,Na, Younghwa
experimental part, p. 1319 - 1325 (2010/09/18)
Tyrosinase ubiquitously existing from microorganisms to animals and plants is known to be the most critical and rate limiting enzyme during melanin biosynthesis. In order to develop new tyrosinase inhibitor we have synthesized 14 diphenyl ether compounds
