54295-49-7Relevant academic research and scientific papers
Synthesis of bicyclic N-methylpyrazoline and pyrazole derivatives from α,β-unsaturated ketones and N,N-dimethylhydrazine: An illustration of reductive cyclization
Panda,Das,Quail,Dimmock
, p. 219 - 223 (2014/02/14)
The reaction of N,N-dimethylhydrazine with α,β-unsaturated keto precursors such as 2-benzylidenecyclohexanone, 2,6-bis(benzylidene) cyclohexanone, and 3,5-bis(benzylidene)-1-methyl-4-piperidone hydrochloride provided bicyclic N-methylpyrazoles instead of hydrazones or any Michael addition products. The crystal structure of a representative pyrazole is reported. The proposed mechanism for the formation of the bicyclic N-methylpyrazole 1 is outlined.
