54299-50-2

Usage

Uses

Used in Pharmaceutical Industry:
(E)-1-(2,4-DIHYDROXY-3,6-DIMETHOXY-PHENYL)-3-PHENYL-PROPENONE is used as an anti-cancer agent for its ability to induce apoptosis in cancer cells and inhibit tumor growth. Its diverse biological activities make it a promising candidate for the development of novel therapeutics.
Used in Nutraceutical Industry:
(E)-1-(2,4-DIHYDROXY-3,6-DIMETHOXY-PHENYL)-3-PHENYL-PROPENONE is used as a nutraceutical ingredient for its antioxidant properties, which can contribute to the treatment and prevention of various diseases.
Used in Cosmetic Industry:
(E)-1-(2,4-DIHYDROXY-3,6-DIMETHOXY-PHENYL)-3-PHENYL-PROPENONE is used as an active ingredient in cosmetics for its anti-inflammatory and anti-aging effects, potentially improving skin health and appearance.
Used in Agricultural Industry:
(E)-1-(2,4-DIHYDROXY-3,6-DIMETHOXY-PHENYL)-3-PHENYL-PROPENONE is used as a bioactive compound in the agricultural industry for its anti-microbial and anti-viral properties, potentially serving as a natural alternative for pest and disease control in crops.

InChI:InChI=1/C17H16O5/c1-21-14-10-13(19)17(22-2)16(20)15(14)12(18)9-8-11-6-4-3-5-7-11/h3-10,19-20H,1-2H3/b9-8+

Upstream product

• 20032-42-2 2,5-dimethoxyresorcinol 
• 102-92-1 cinnamoyl chloride 
• 6274-74-4 2,6-dibenzyloxy-1,4-dimethoxybenzene 
• 42528-81-4 2,6-bis-benzyloxy-benzene-1,4-diol 
• 6625-45-2 2,6-bis-benzyloxy-[1,4]benzoquinone 
• 55020-64-9 1,2,3-tris-benzyloxybenzene 
• 87-66-1 2-hydroxyresorcinol 

Downstream Products

• 1969289-10-8 (-)-celosine 
• 1969289-10-8 (+)-celosine 
• 3316-54-9 7-hydroxy-5,8-dimethoxyflavone 
• 632-85-9 wogonin 

Relevant academic research and scientific papers

Synthesis, evaluation and quantitative structure–activity relationship (QSAR) analysis of Wogonin derivatives as cytotoxic agents

A novel series of 49 wogonin derivatives were synthesized by introducing group at 7-, 8- or B ring of wogonin. The cytotoxic activities against HepG2, A549 and BCG-823 cancer cell lines were also investigated in vitro. Several of them showed obvious cytotoxic activities and compound 3h possessed the highest potency against HepG2, A549, and BCG-823 with IC50 values of 1.07 μM, 1.74 μM and 0.98 μM, respectively. A quantitative structure-activity relationship (QSAR) study of these synthetic derivatives as well as wogonin indicated that high solubility and low octanol/water partition coefficient are favorable, and excessive electrostatic properties and refractivity are unfavorable for the cytotoxic activities of these wogonin derivatives. These findings and results provide a base for further investigations.

Isolation, structure elucidation, and KDD study of (-)-Celosine, a new skeleton with potent anti-atherosclerosis activity

Natural (-)-Celosine was isolated as a novel endocyclicditerpene with an unprecedented skeleton from Celosia cristata L. Its structure was established by comprehensive 1D and 2D NMR spectroscopic analysis in combination with single-crystal X-ray crystallographic diffraction of synthesized (+)-Celosine. (-)-Celosine was expected to have an anti-atherosclerotic activity in vivo, and myeloperoxidase (MPO) expression may be the mechanism underlying this anti-atherosclerotic activity.