54301-26-7Relevant academic research and scientific papers
Polyanion Inhibitors of Human Immunodeficiency Virus and Other Viruses. 1. Polymerized Anionic Surfactants
Leydet, A.,Barthelemy, Ph.,Boyer, B.,Lamaty, G.,Rogue, J. P.,et al.
, p. 2433 - 2440 (1995)
A series of polyanionic compounds was synthesized and evaluated for their activity against human immunodeficiency virus (HIV-1, HIV-2) and various other RNA and DNA viruses.Several compounds, i.e., 2p, 3p, 8p, 13p, 14p, 15p, 17p, 18p, and 19p, proved active against HIV-1 within the concentration range of 0.1-3μg/mL while not being toxic to the host cells (CEM, MT-4) at concentrations up to 100 μg/mL or higher.As a rule, these polyanionic compounds proved also active, albeit at somewhat higher concentrations than those required for HIV-1 inhibition, against a number of other enveloped viruses, including HIV-2, human cytomegalovirus, influenza A virus, respiratory syncytial virus, and arenaviruses (Junin and Tacaribe).Among the most potent HIV-1 inhibitors ranked compounds 18p and 19p, the sodium salts of N-methylamides obtained by polymerization of monomers prepared starting from 10-undecenoyl chloride and ω-aminoalkanoic acids.
SULFONIC ACID, CARBOXYLIC ACID, AND SALTS THEREOF
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Paragraph 0371-0374, (2020/02/10)
A sulfonic acid or carboxylic acid containing a carbonyl group, or a salt thereof represented by the following formula: [in-line-formulae]R1—C(═O)—(CR22)—(OR3)p—(CR42)q-L-A[/in-line-formulae] wherein R1, R2, R3, R4, n, p, q, A and L are as defined herein.
