5431-39-0

Usage

Uses

Used in Pharmaceutical Industry:
7-chloro-N-(4-chlorophenyl)quinolin-4-amine is used as a key intermediate in the synthesis of various pharmaceuticals for its potential biological activities, such as antimalarial and anticancer properties. Its unique structure allows for the development of new drugs targeting specific diseases.
Used in Agrochemical Industry:
7-chloro-N-(4-chlorophenyl)quinolin-4-amine is used as a building block in the synthesis of agrochemicals, contributing to the development of effective pesticides and other agricultural products.
Used in Antimalarial Applications:
7-chloro-N-(4-chlorophenyl)quinolin-4-amine is studied for its potential antimalarial properties, offering a new avenue for the development of treatments against malaria.
Used in Anticancer Applications:
7-chloro-N-(4-chlorophenyl)quinolin-4-amine is investigated for its anticancer properties, with the potential to be developed into new therapeutic agents for the treatment of various types of cancer.
Used in Anti-inflammatory Applications:
7-chloro-N-(4-chlorophenyl)quinolin-4-amine is studied for its anti-inflammatory properties, which may lead to the development of new treatments for inflammatory diseases.
Used in Antimicrobial Applications:
7-chloro-N-(4-chlorophenyl)quinolin-4-amine is researched for its antimicrobial properties, potentially contributing to the development of new antibiotics and antifungal agents to combat drug-resistant infections.

Upstream product

• 86-98-6 4,7-dichloroquinoline 
• 106-47-8 4-chloro-aniline 

Relevant academic research and scientific papers

Preparation method of intermediate for leukemia treatment medicines

The invention belongs to the technical field of chemical medicines, and specifically relates to a preparation method of an intermediate for leukemia treatment medicines. The method comprises the stepsof supporting N-[3-(triethoxysilyl)propyl]-4,5-dihydroi

Trifluoroacetic acid in 2,2,2-trifluoroethanol facilitates SNAr reactions of heterocycles with arylamines

Small-molecule drug discovery requires reliable synthetic methods for attaching amino compounds to heterocyclic scaffolds. Trifluoroacetic acid-2,2,2-trifluoroethanol (TFA-TFE) is as an effective combination for achieving SNAr reactions between

Structural optimization of quinolon-4(1 H)-imines as dual-stage antimalarials: Toward increased potency and metabolic stability

Discovery of novel effective and safe antimalarials has been traditionally focused on targeting erythrocytic parasite stages that cause clinical symptoms. However, elimination of malaria parasites from the human population will be facilitated by intervent

Microwave-accelerated solvent- and catalyst-free synthesis of 4-aminoaryl/alkyl-7-chloroquinolines and 2-aminoaryl/alkylbenzothiazoles

An efficient synthesis of 4-aminoaryl/alkyl-7-chloroquinolines and 2-aminoaryl/alkylbenzothiazoles has been developed by microwave-accelerated regioselective aromatic nucleophilic substitution of 4,7-dichloroquinoline and 2-chlorobenzothiazole with aromatic and aliphatic amines under solvent-free conditions in the absence of any added protic or Lewis acid catalyst. Chemoselective reaction with the amino group in preference to the phenolic hydroxy group was observed. Thus, the treatment of 4,7-dichloroquinoline (1 equiv.) with a mixture of aniline (2 equiv.) and phenol (2 equiv.) afforded exclusive formation of 4-aminophenyl-7-chloroquinoline. When 4,7-dichloroquinoline (1 equiv.) was separately treated with 2-aminophenol (2 equiv.) and 4-aminophenol (2 equiv.), 4-(2'-hydroxyphenyl)-7-chloroquinoline and 4-(4'-hydroxyphenyl)-7-chloroquinoline, respectively, were formed. CSIRO 2007.