5431-97-0

Usage

Uses

Used in Pharmaceutical Industry:
2,3-dibromo-3-(3-chlorophenyl)propanoic acid is used as a key intermediate in the synthesis of pharmaceuticals for its ability to contribute to the development of chiral drugs. Its chiral nature allows for the creation of drugs with specific stereochemistry, which can be crucial for their efficacy and safety.
Used in Agrochemical Industry:
In the agrochemical industry, 2,3-dibromo-3-(3-chlorophenyl)propanoic acid is employed as a building block in the synthesis of agrochemicals, contributing to the development of effective and targeted pest control agents.
Used in Organic Synthesis:
2,3-dibromo-3-(3-chlorophenyl)propanoic acid is used as a versatile intermediate in organic synthesis, enabling the preparation of a wide range of biologically active compounds with potential applications in various fields.
Used as a Reference Standard in Analytical Testing:
2,3-dibromo-3-(3-chlorophenyl)propanoic acid is utilized as a reference standard in analytical testing, ensuring the accuracy and reliability of test results by providing a known quantity and quality of the compound for comparison.
Used as a Reagent in Organic Reactions:
In organic reactions, 2,3-dibromo-3-(3-chlorophenyl)propanoic acid serves as a reagent, facilitating various chemical transformations and contributing to the synthesis of complex organic molecules.

Upstream product

• 1866-38-2 3-chlorocinnamic acid 
• 1866-38-2 m-Chlorocinnamic acid 
• 587-04-2 m-Chlorobenzaldehyde 
• 121263-06-7 (3-chloro-benzylidene)-malonic acid 

Downstream Products

• 143231-53-2 α-bromo-3-chloro-trans-cinnamic acid 
• 1607020-84-7 N-isobutyl-3-exo-(3-chlorobenzylidene)tricyclo[3.2.1.02,4]octane-6,7-endo-dicarboximide 
• 1607020-88-1 3-exo-(3-chlorobenzylidene)tricyclo[3.2.1.02,4]octane 
• 76557-95-4 (Z)-1-(2-bromovinyl)-3-chlorobenzene 
• 1607020-77-8 N-(4-methylphenyl)-3-exo-(4-chlorobenzylidene)tricyclo[3.2.1.0^2,4]octane-6,7-endo-dicarboximide 
• 35225-01-5 4-(3-chlorophenyl)-1H-1,2,3-triazole 
• 143231-54-3 α-bromo-3-chloro-cis-cinnamic acid 

Relevant academic research and scientific papers

Palladium-Catalyzed Two-Component Domino Coupling Reaction of (Z)-β-Bromostyrenes with Norbornenes: Synthesis of 1,5-Enynes

Polyfunctional molecules, 1,5-enynes, have been achieved via a palladium(0)-catalyzed domino coupling reaction of (Z)-β-bromostyrenes with norbornenes in the presence of cesium carbonate and N,N-dimethylformamide. The process involves a double Heck-type procedure, two-fold C(sp2) H activation and formation of two carbon-carbon bonds. There are possibilities of diversified transformation for the domino coupling of (Z)-β-bromostyrenes with norbornenes, the procedure is successfully driven to 1,5-enynes via accurate adjustment of the reaction conditions. (Figure presented.) .

Palladium(0)-Catalyzed Methylcyclopropanation of Norbornenes with Vinyl Bromides and Mechanism Study

An unusual methylcyclopropanation from [2 + 1] cycloadditions of vinyl bromides to norbornenes catalyzed by Pd(OAc)2/PPh3 in the presence of CH3ONa and CH3OH has been established. A methylcyclopropane subunit was installed by a 3-fold domino procedure involving a key protonation course. Preliminary deuterium-labeling studies revealed that the proton came from methyl of CH3OH and also exposed an additional hydrogen/deuterium exchange process. These two proton-concerned reactions were fully chemoselective.

Palladium(0)-catalyzed methylenecyclopropanation of norbornenes with vinyl bromides

Highly strained methylenecyclopropane derivatives have been achieved via a novel and efficient Pd(0)-catalyzed domino reaction. The formal [2 + 1] cycloaddition reaction of vinyl bromides to norbornenes involves a Heck-type coupling and a C(sp2)-H bond activation.

Palladium-catalyzed [2+1+1] annulation of norbornenes with (z)-bromostyrenes: Synthesis of bismethylenecyclobutanes via twofold C(sp2)-H bond activation

The first Pd-catalyzed intermolecular [2+1+1] annulation reaction of (Z)-bromostyrene derivatives and norbornenes has been realized. Bismethylenecyclobutane derivatives were obtained with high yields. The domino coupling reaction involves a double Heck-type coupling process, twofold C(sp2)-H bond activation and formation of three carbon-carbon bonds.