5432-97-3

Usage

Uses

Used in Organic Synthesis:
1-(naphthalen-2-ylsulfanyl)naphthalen-2-ol is used as a building block in organic synthesis for the preparation of various organic compounds. Its unique structure with a thiol and hydroxyl group allows for a wide range of chemical reactions, contributing to the diversity of synthesized products.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 1-(naphthalen-2-ylsulfanyl)naphthalen-2-ol is used as a precursor for the development of new drugs. Its versatile reactivity and structural features make it a promising candidate for creating novel therapeutic agents.
Used in Research:
1-(naphthalen-2-ylsulfanyl)naphthalen-2-ol is also utilized in research settings to study its chemical properties and potential applications. 1-(naphthalen-2-ylsulfanyl)naphthalen-2-ol's reactivity and structural characteristics provide valuable insights for scientists working on the development of new materials and drug candidates.
Used in the Synthesis of Functional Materials:
1-(naphthalen-2-ylsulfanyl)naphthalen-2-ol is used as a precursor in the synthesis of various functional materials. The presence of both a thiol and a hydroxyl group in its structure makes it a valuable component in the creation of materials with specific properties for different applications.

Upstream product

• 5586-15-2 bis(2-naphthyl)disulfide 
• 875-83-2 sodium 2-naphtholate 
• 135-19-3 β-naphthol 
• 91-60-1 2-Naphthalenethiol 
• 573-97-7 1-bromo-2-naphthol 
• 529-36-2 1-Naphthalenethiol 
• 10151-46-9 2-naphthylsulfonyl hydrazide 

Relevant academic research and scientific papers

An alternative synthetic path to 1-substituted 2-naphthol

The photoinduced substitution of the 2-naphthoxide anion was carried out using diethylphosphite, benzenethiolate or 2-naphthalenethiolate anions in the presence of an electron acceptor. The corresponding products were afforded in good yield. This is a sim

Microwave assisted synthesis of 1-(arylthio)naphthalen-2-ols and their antimicrobial activity

A series of 1-(arylthio)naphthalen-2-ols have been synthesized by condensation of naphthalen-2-ol with 1,2-diaryldisulfanes in the presence of iodine under microwave irradiation and conventional heating methods. Structures of the products were elucidated

Aerobic Cross-Dehydrogenative Coupling Reactions for Selective Mono- And Dithiolation of Phenols

A highly efficient strategy for the direct thiolation of phenols under transition metal-free and solvent-free conditions has been developed. These reactions are operationally simple with employing air (molecular oxygen) as an ideal oxidant and can selectively provide mono- and dithiolation products in good to excellent yields under basic conditions. The reaction tolerates a broad range of aryl thiols and arenes and is especially applicable for large-scale synthesis.

TBAI-mediated sulfenylation of arenes with arylsulfonyl hydrazides in DPDME

An efficient TBAI (tetrabutylammonium iodide)-mediated C–H sulfenylation of arenes with arylsulfonyl hydrazides in dipropylene glycol dimethyl ether (DPDME) was described. Various electron-rich arenes were applicable in the reaction, such as naphthylamine, naphthol, aniline, indole, pyrrole, and imidaz o [1,2-a] pyridine. A wide range of the aryl sulfides were obtained with good functional group tolerance. This method features green reaction conditions (odorless and easily available sulfur reagent, recyclable TBAI, and DPDME as solvent), and broad substrate scope. The synthetic potential is demonstrated by gram-scale synthesis and downstream transformations. The mechanism studies show that the reaction is achieved through electrophilic substitution process, and diaryl disulfide may be the main intermediate.

Metal free, facile sulfenylation of ketene dithioacetals catalyzed by an HBr-DMSO system

A transition metal free, highly efficient, sulfenylation of ketene dithioacetals catalyzed by an HBr-DMSO system is achieved. This strategy employs inexpensive and readily available HBr and DMSO to provide a direct C-H bond sulfenylation with a broad rang

Cobalt-Catalyzed Aerobic Cross-Dehydrogenative Coupling of C-H and Thiols in Water for C-S Formation

Organosulfides have great significance and value in synthetic and biological chemistry. To establish a versatile and green methodology for C-S bond generation, we successfully developed a new aerobic cross-dehydrogenative coupling of C-H and S-H to synthe

Photoinitiated Synthesis of Sulfides in Water

Herein, we report a synthetic route to obtain aryl sulfides using inexpensive and non-toxic reactants and water as solvent, that avoids the use of catalysts or heating. The photoinduced reaction between soluble substrates and a series of thiols in alkaline aqueous medium produces the corresponding sulfides in moderate to good yields.

Iodine catalyzed cross-dehydrogenative C-S coupling by C(sp2)-H bond activation: Direct access to aryl sulfides from aryl thiols

A novel, efficient and unprecedented green protocol for the formation of C-S bonds has been developed under metal-free conditions. This protocol involves the synthesis of aryl sulfides through the cross-dehydrogenative coupling of readily available aryl t

Sulfenylation of nitroalkanes and hydroxyaryls

The sulfenylation of nitroalkanes and hydroxyaryls in DMSO using aryl disulfides as sulfenylating reagents was studied. The corresponding arylthionitroalkanes and arylthiohydroxyaryls were obtained in moderate to good yields in very mild conditions, thus improving the reported procedures for the synthesis of these compounds.