875-83-2Relevant academic research and scientific papers
Feasible Approach to Tricyclic and Tetracyclic cyclododecanone
Zoorob, Hanafi H.,Elsherbini, Mohamed S.,Hamama, Wafaa S.
, p. 941 - 944 (2016/05/19)
2-Bromocyclododecanone was utilized as precursor to synthesize polyfused heterocyclic cyclododecane ring systems. Transformation of 2-bromocyclododecanone (5) with 1H-benzimidazole-2-thiole (6), benzo[d]thiazole-2-thiol (9), 2-naphthol (12), and thiophenol (15) afforded thiazolo[2,3-b]benzimidazole (8), thiazolo[2,3-b]benzothaizole derivative (11) naphtho[1,2-d]furan derivative (14) and 2-(phenylthio)cyclododecanone (16), respectively.
METHODS FOR PREPARING FLUOROALKYL ARYLSULFINYL COMPOUNDS AND FLUORINATED COMPOUNDS THERETO
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Page/Page column 65; 66, (2010/04/03)
Novel preparative methods for fluoroalkyl arylsulfinyl compounds are disclosed. Fluorinated compounds as useful fluorinated compounds, intermediates, or builing blocks are disclosed. Useful applications of the fluoroalkyl arylsulfinyl compounds are shown.
VIRAL POLYMERASE INHIBITORS
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Page/Page column 97, (2009/04/25)
Compound of Formula I: wherein, R2, R5 and R6 are defined herein, are useful as inhibitors of the hepatitis C virus NS5B polymerase
BICYCLIC MELANOCORIN-SPECIFIC COMPOUNDS
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Page/Page column 29-32, (2010/02/13)
Melanocortin receptor-specific bicyclic compounds having the structure (I) and stereoisomer and pharmaceutically acceptable salts thereof, where R1,R2,R3 X and z are as described in the specification, which are agonists, antagonists or mixed agonists and antagonists at one or more melanocortin receptors, and having utility in the treatment of melanocortin receptor-related disorders and conditions. Pharmaceutical compositions containing a compound of structure (I) and methods relating to the use thereof are also disclosed.
Process for dehydrating hydrous sodium Beta-naphtholate
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Page/Page column 4; 5, (2010/02/10)
The present invention provides a process for dehydrating hydrous sodium β-naphtholate comprising: the step of heating the hydrous sodium β-naphtholate or a mixture of the hydrous sodium β-naphtholate and β-naphthol which comprises no more than 0.2 mole of β-naphthol per one mole of sodium β-naphtholate in a solvent at a temperature of 260-300°C under an inert gas. The process makes it possible to dehydrate hydrous sodium β-naphtholate thoroughly in a short time with less production of tarry components.
Arylalkylheterocyclic amines,N-substituted by aryloxyalkyl group in a method for allergy treatment
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, (2008/06/13)
A method of inhibiting Type 1 allergic responses in a living animal body with substituted heterocyclic amines is disclosed wherein the active agents are expressed generally by the formula which includes certain known and certain known compounds: STR1 wherein P is zero, one or two; m is one to six inclusive; A is selected from hydrogen, hydroxy or cyano; d is zero or one; Q is --CH--, CH2 -- or STR2 n is zero or one and when Q is --CH-- and n is one, a double bond is formed with one of the adjacent carbons but not both at the same time, and when n and d are zero at the same time, a double bond is formed between the α carbon and a carbon of the central heterocyclic amine ring; Ar, D and R are selected from phenyl, substituted phenyl, pyridinyl, thienyl, furanyl or naphthyl and in addition, R may have the values benzyl, substituted benzyl, cycloalkyl or loweralkyl and D may additionally have the values: 2H-1-benzopyran-2-one,4-oxo-4H-1-benzopyran-2-carboxylic acid loweralkyl ester, 2,3-dihydro-4H-1-benzopyran-4-one, 1,4-benzodioxanloweralkyl-2-yl or 1,1'-biphenyl-4-yl and the pharmaceutically acceptable salts thereof.
Process for producing 2 hydroxy-naphthalene-3-carboxylic acid
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, (2008/06/13)
A process for producing 2-hydroxynaphthalene-3-carboxylic acid comprising reacting carbon dioxide with a homogeneous liquid mixture comprising an alkali metal salt of β-naphthol, β-naphthol and a specific alkylbenzene is disclosed.
Process for the manufacture of anhydrous alkali metal arylate solutions and separation of the arylates from alkali metal sulfite
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, (2008/06/13)
Anhydrous organic solutions of alkali metal arylates are prepared by dissolving an alkali metal arylate or reacting an arylhydroxy compound with alkali metal hydroxide in a ketone immiscible or incompletely miscible with water at room temperature and removing the water from the solution, if any, by azeotropic distillation with reflux.
