54322-74-6

Upstream product

• 116211-30-4 (bromo(cyclohexyl)methyl)benzene 
• 24850-33-7 allyltributylstanane 
• 762-72-1 allyl-trimethyl-silane 
• 54322-72-4 (1-chlorobut-3-en-1-yl)benzene 
• 931-50-0 cyclohexylmagnesium bromide 

Relevant academic research and scientific papers

Facile Direct Coupling Reactions of MOM-protected Benzylic Alcohols Using Aluminum Chloride

MOM group is one of the most commonly used protecting groups for alcohols. This study describes novel direct functionalization of the MOM-protected benzylic alcohols. Preparation of allylic compounds from benzyl MOM ethers was successfully achieved by utilization of allyltrimethylsilane and AlCl3. In addition, direct azidation of benzyl MOM ethers using TMSN3 was successful carried out under AlCl3-mediated reaction conditions. These results demonstrate that this novel synthetic procedure is a promising approach to direct functionalization of MOM-protected alcohols including allylation and azidation.

Radical reaction initiated and stereocontrolled by zinc chloride

The reaction of allyltributyltin with methyl 2-[N-((4S)-4-(1-methylethyl)-2-oxazolidinone-3-carbamoyl)amino]-2-bromoacetate (5 a) was accelerated at -50°C in the presence of AIBN and stopped in the presence of galvinoxyl, indicating that the reaction proceeds through a radical mechanism. The reaction was accelerated dramatically at -78°C in the presence of ZnCl2·OEt2, and the ZnCl2-mediated reaction was stopped in the presence of galvinoxyl. In the presence of 2 equiv ZnCl2·OEt2, the reaction afforded methyl (2R)-2-[N-((4SH-(1-methylethyl)-2-oxazolidinone-3-carbamoyl)amino]-4-pentenoate {6a(R)} with high diastereoselectivity (93:7). Taken together, ZnCl2·OEt2 works as a radical initiator as well as chelating agent.

All ring compounds-XXIX. Thermal decomposition of t-butyl per (trans-2-substituted cyclopropyl) acetates

Three kinds of t-butyl per (trans-2-substituted cyclopropyl) acetates (RH, CH3, C6H5) were synthesized from the corresponding acyl chlorides and thermally decomposed in cyclohexane to investigate the chemical stability and behaviour of the cyclopropylcarbinyl radical. Clean first-order kinetics were obtained in all of the thermal decomposition reactions. The experimental fact that the decompositoin rates and activation parameters of these three t-butyl peresters are similar to each other may indicate the absence of the ionic character in the transition state suggesting the almost complete homolytic decomposition of these peresters. Although the typical concerted decomposition might be invalid for these peresters in view of the activation parameters, it would be suggested from the product studies that the decomposition of these peresters was characterized by a considerable loss of their acyl-alky] bonds at the time of the fission of their OO bonds. The products yielded from the thermal decomposition of t-butyl per (trans-2-phenylcyclopropyl) acetate in various hydrogen donating solvents consisted of three hydrocarbons and two t-butyl ethers. The formation of these t-butyl ethers, possibly cage products, was significant.