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N-[4-(Pyrazin-2-ylsulfamoyl)phenyl]acetamide is a chemical compound with the molecular formula C12H11N3O3S. It is a derivative of acetamide, featuring a pyrazine-2-sulfonamide group attached to a phenyl ring. N-[4-(pyrazin-2-ylsulfamoyl)phenyl]acetamide is known for its potential applications in medicinal chemistry, particularly as a building block for the synthesis of various pharmaceuticals. Its structure allows for the exploration of different biological activities, making it a subject of interest in drug discovery and development. The compound's specific properties and reactivity are influenced by the presence of the sulfonamide group, which can form hydrogen bonds and engage in other interactions that are crucial for its potential therapeutic effects.

5433-91-0

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5433-91-0 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 5433-91-0 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 5,4,3 and 3 respectively; the second part has 2 digits, 9 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 5433-91:
(6*5)+(5*4)+(4*3)+(3*3)+(2*9)+(1*1)=90
90 % 10 = 0
So 5433-91-0 is a valid CAS Registry Number.

5433-91-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name N-[4-(pyrazin-2-ylsulfamoyl)phenyl]acetamide

1.2 Other means of identification

Product number -
Other names N-Acetyl-sulfanilsaeure-pyrazin-2-ylamid

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:5433-91-0 SDS

5433-91-0Downstream Products

5433-91-0Relevant academic research and scientific papers

Substituted N-(Pyrazin-2-yl)benzenesulfonamides; Synthesis, anti-infective evaluation, cytotoxicity, and in silico studies

Bouz, Ghada,De La Red, Cristina Paredes,Dole?al, Martin,Jand'Ourek, Ond?ej,Janou?ek, Ji?í,Juhás, Martin,Kone?ná, Klára,Kubí?ek, Vladimír,Otero, Lluis Pausas,Paterová, Pavla,Zitko, Jan

, (2020/01/13)

We prepared a series of substituted N-(pyrazin-2-yl)benzenesulfonamides as an attempt to investigate the effect of different linkers connecting pyrazine to benzene cores on antimicrobial activity when compared to our previous compounds of amide or retro-amide linker type. Only two compounds, 4-amino-N-(pyrazin-2-yl)benzenesulfonamide (MIC = 6.25 μg/mL, 25 μM) and 4-amino-N-(6-chloropyrazin-2-yl)benzenesulfonamide (MIC = 6.25 μg/mL, 22 μM) exerted good antitubercular activity against M. tuberculosis H37Rv. However, they were excluded fromthe comparison as they-unlike the other compounds-possessed the pharmacophore for the inhibition of folate pathway, which was proven by docking studies. We performed target fishing, where we identified matrixmetalloproteinase-8 as a promising target for our title compounds that isworth future exploration.

3-PHOSPHOGLYCERATE DEHYDROGENASE INHIBITORS AND USES THEREOF

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Paragraph 00293, (2017/10/06)

The present invention provides compounds, compositions thereof, and methods of using the same.

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