116-44-9

Usage

Uses

Used in Pharmaceutical Industry:
Pyrazinamide is used as an anti-tuberculosis agent for its ability to effectively target and eliminate the bacteria causing tuberculosis. It is often administered in combination with other anti-tuberculosis drugs to enhance treatment efficacy and combat drug resistance.
Used in Tuberculosis Treatment:
Pyrazinamide is used as a key component in the treatment of tuberculosis, where it plays a crucial role in disrupting the bacteria's ability to produce RNA and DNA, ultimately leading to their death. This action helps in controlling the spread of the disease and improving patient outcomes.
However, it is important to note that pyrazinamide may cause side effects such as liver damage, gastrointestinal disturbances, and skin rashes in some individuals. Therefore, it is essential to monitor patients closely during treatment to ensure safety and effectiveness.

InChI:InChI=1/C10H10N4O2S/c11-8-1-3-9(4-2-8)17(15,16)14-10-7-12-5-6-13-10/h1-7H,11H2,(H,13,14)

Upstream product

• 14508-49-7 2-chloropyrazin 
• 63-74-1 sulfanilamide 
• 5433-91-0 N-(4-(N-(pyrazin-2-yl)sulfamoyl)phenyl)acetamide 
• 121-61-9 p-acetylaminobenzenesulfonamide 
• 121-60-8 p-acetylaminobenzenesulfonyl chloride 

Downstream Products

• 97810-63-4 3-oxo-2-(4-pyrazin-2-ylsulfamoyl-phenylhydrazono)-butyric acid ethyl ester 
• 139445-61-7 4-[N'-(1-Acetyl-2-oxo-propylidene)-hydrazino]-N-pyrazin-2-yl-benzenesulfonamide 
• 139445-69-5 3-Methyl-5-oxo-4-{[4-(pyrazin-2-ylsulfamoyl)-phenyl]-hydrazono}-4,5-dihydro-pyrazole-1-carbothioic acid amide 

Relevant academic research and scientific papers

Substituted N-(Pyrazin-2-yl)benzenesulfonamides; Synthesis, anti-infective evaluation, cytotoxicity, and in silico studies

We prepared a series of substituted N-(pyrazin-2-yl)benzenesulfonamides as an attempt to investigate the effect of different linkers connecting pyrazine to benzene cores on antimicrobial activity when compared to our previous compounds of amide or retro-amide linker type. Only two compounds, 4-amino-N-(pyrazin-2-yl)benzenesulfonamide (MIC = 6.25 μg/mL, 25 μM) and 4-amino-N-(6-chloropyrazin-2-yl)benzenesulfonamide (MIC = 6.25 μg/mL, 22 μM) exerted good antitubercular activity against M. tuberculosis H37Rv. However, they were excluded fromthe comparison as they-unlike the other compounds-possessed the pharmacophore for the inhibition of folate pathway, which was proven by docking studies. We performed target fishing, where we identified matrixmetalloproteinase-8 as a promising target for our title compounds that isworth future exploration.

3-PHOSPHOGLYCERATE DEHYDROGENASE INHIBITORS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same.

Process for formulating a synthetic drug for use in animal feed, and resulting formulation

A method of formulating a synthetic drug for use in animal feed, for the purpose of reducing carry-over of the synthetic drug to subsequent lots of animal feed in the feed mill.