5435-40-5

Usage

Uses

Used in Pharmaceutical Industry:
2-(2,5-dimethyl-1H-indol-3-yl)acetic acid is used as a chemical compound for the development of new drugs for the treatment of various medical conditions. Its unique structure and properties make it a potentially valuable molecule for medicinal chemistry research and drug discovery.
Further studies and research are needed to fully understand the pharmacological and biological activities of 2-(2,5-dimethyl-1H-indol-3-yl)acetic acid.

InChI:InChI=1/C12H13NO2/c1-7-3-4-11-10(5-7)9(6-12(14)15)8(2)13-11/h3-5,13H,6H2,1-2H3,(H,14,15)

Upstream product

• 637-60-5 p-tolylhydrazine hydrochloride 
• 123-76-2 levulinic acid 
• 7515-90-4 4-p-tolylhydrazono-valeric acid 
• 1196-79-8 2,5-Dimethyl-1H-indole 
• 50-00-0 formaldehyd 
• 151-50-8 potassium cyanide 

Relevant academic research and scientific papers

Discovery of selective indole-based prostaglandin D2 receptor antagonist

A series of N-benzoyl-2-methylindole-3-acetic acids were synthesized and biologically evaluated as prostaglandin (PG) D2 receptor antagonists. Some of the selected compounds significantly inhibited OVA-induced vascular permeability in guinea pig conjunctiva after oral dosing. Structure-activity relationship study is presented.

Compounds exhibiting thrombopoietin-like activities

The compounds of the invention are compounds represented by the following general formula (1): wherein E represents one selected from the group consisting of a methylidyne group and a nitrilo group, R1 represents one selected from the group consisting of optionally substituted aryl groups and optionally substituted heteroaryl groups, R2 represents one selected from the group consisting of a hydrogen atom and alkyl groups, W1 represents an amino acid residue, A represents one selected from the group consisting of a carbonyl group and a sulfonyl group, X1 represents one selected from the group consisting of optionally substituted alkylene groups and optionally substituted alkenylene groups, and p represents 0 or 1; and their pharmacologically acceptable salts, which exhibit thrombopoietin-like activity.