54359-59-0Relevant academic research and scientific papers
AMIDE DERIVATIVES AS SIRTUIN MODULATORS
-
Page/Page column 160-161, (2009/06/27)
Provided herein are novel sirtuin-modulating compounds represented by Structural Formula (I) and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benfit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin- modulating compound in combination with another therapeutic agent.
Ring Transformation of 3,1-Benzothiazin-2,4-dithiones with Carboxylic Acid Hydrazides to Substituted 1,3,4-Thiadiazoles or in the Presence of Hydroxid Ions to 3-Acylamino-quinazolin-2,4-dithiones
Leistner, Siegfried,Hentschel, Karin,Wagner, Guenther
, p. 915 - 922 (2007/10/02)
The substituted 1,3,4-thiadiazoles 4-14 were prepared in one step by reaction of 3,1 benzothiazin-2,4-dithiones 1 and 3 with RCONHNH2 (R=Me, Ph, substituted Ph, 4-Pyridyl, CONHNH2).Reaction of 1 with RCONHNH2 in the presence of HO(-) leads to substituted quinazolin-2,4-dithiones 18-20.Under the action of CS2 the yield of 19 and 20 increases.Possible reaction mechanisms are discussed. - keywords: 2H-3,1-Benzothiazin-2,4(1H)-dithione; Carbocyclic acid hydrazides; Quinazolin-2,4(1H,3H)-dithione; Ring transformation; 1,3,4-Thiadiazoles
