5437-26-3

Usage

Uses

Used in Pharmaceutical Industry:
1-(3-nitrophenyl)-2-(quinolin-2-yl)ethanol is used as a potential pharmaceutical agent for its anti-inflammatory and antioxidant properties, which can be beneficial in the development of new medications targeting inflammation and oxidative stress-related conditions.
Used in Organic Synthesis:
1-(3-nitrophenyl)-2-(quinolin-2-yl)ethanol is used as a building block in organic synthesis, particularly for creating molecules with potential applications in various industries, including pharmaceuticals, agrochemicals, and materials science.
Used in Medicinal Chemistry Research:
NQETH is used as a subject of study in medicinal chemistry research to explore its potential as a biologically active compound and to understand its interactions with biological targets, which could lead to the development of new therapeutic agents.

Upstream product

• 91-63-4 2-methylquinoline 
• 619-25-0 3-Nitrobenzyl alcohol 
• 99-61-6 3-nitro-benzaldehyde 

Relevant academic research and scientific papers

α-Chymotrypsin–catalyzed direct C (Sp3)–H functionalization reactions for synthesis of azaarene derivatives in water

α-Chymotrypsin from the bovine pancreas has been shown for the first time to display catalytic nonnatural catalytic ability toward the C (sp3)–H functionalization reaction of 2-methylquinoline and aromatic aldehydes in water. α-Chymotrypsin exhibited favorable catalytic activity with good adaptability to different substrates. The activity of the enzyme could be improved by adjusting the solvent, temperature, molar ratio of substrates, and protein loading. The products were obtained in moderate to excellent yields (51%-93%) in 24 samples. This process afforded a potential biocatalytic approach as an alternative to chemical synthesis for azaarene derivatives.

Method for preparing 1-aryl-2-quinolyl ethanol compound by catalysis of acidic ionic liquid

The invention discloses a method for preparing a 1-aryl-2-quinolyl ethanol compound by catalysis of acidic ionic liquid and belongs to the technical field of chemical material preparation. The methodfor preparing the 1-aryl-2-quinolyl ethanol compound by

A synthesis method of pyridine and quinoline derivatives

The invention discloses a method for synthesizing pyridine and quinoline derivative. The method for synthesizing the pyridine and quinoline derivative comprises the following steps: heating and carrying out reaction on a pyridine or quinoline compound A and an aldehyde compound B in an ionic liquid [Bmim]BF4, wherein an ionic liquid [Hnhm]HSO4 is taken as a catalyst, and pyridine and quinoline derivative C can be obtained after reaction is carried out for a period of time. The catalyst [Hmim]H2PO4 and the solvent [Bmim]BF4 which are used in the reaction can be recycled and utilized for eight times, and yield of a final product is not obviously reduced; therefore, the method for synthesizing the pyridine and quinoline derivative can reduce experimental cost to the utmost extent and reduce environmental pollution and has a good application prospect. The reaction formula is described in the specification.

Magnetically separable CuFe2O4 nanoparticles as a recoverable catalyst for the addition reaction of C(sp3)-H bond of azaarenes to aldehydes

A green and efficient protocol for the copper ferrite (CuFe2O4) nanoparticle-catalyzed direct C(sp3)-H bond functionalization of 2-alkyl azaarenes has been developed. The magnetic catalyst can be recovered and recycled by a simple magnetic separation from the reaction solution and reused eight times without significant decrease in catalytic activity. This journal is

Acid ionic liquid promoted addition of C(sp3)-H bond to aldehyde

A novel protocol for acid ionic liquid promoted C(sp3)-H bond functionalization of alkyl azaarenes and nucleophilic addition to aldehydes was developed in good to excellent yields, which provides an efficient approach for the synthesis of alkyl-substituted azaarene derivatives. It is worthwhile to note that acid ionic liquid used for this reaction can be recycled and reused six times without a significant decrease in activity.

Microwave assisted water mediated benzylic C-H functionalization of methyl aza-arenes and nucleophilic addition to aromatic aldehydes

A highly efficient method is described for the sp3 C-H bond functionalization of methyl aza-arenes in the presence of water under microwave irradiation and subsequent addition to aromatic aldehydes. This transformation represents an efficient way to synthesize 2-alkyl aza-arene derivatives from simple starting materials.