54370-01-3

Basic information

• Product Name: 1-bromo-2-(chloromethyl)-4,5-dimethoxy-benzene
• Synonyms: Toluene,2-bromo-a-chloro-4,5-dimethoxy- (7CI);Veratrole, 4-bromo-5-(chloromethyl)- (6CI); 1-Bromo-2-chloromethyl-4,5-dimethoxybenzene;2-Bromo-4,5-dimethoxybenzyl chloride; 6-Bromo-3,4-dimethoxybenzyl chloride
• CAS NO: 54370-01-3
• Molecular Formula: C₉H₁₀BrClO₂
• Molecular Weight: 265.54
• Mol File: 54370-01-3.mol

Chemical Properties

• Boiling Point: 309.5°C at 760 mmHg
• Flash Point: 141°C
• Appearance: /
• Density: 1.464g/cm³
• Vapor Pressure: 0.00116mmHg at 25°C
• Refractive Index: 1.542
• CAS DataBase Reference: 1-bromo-2-(chloromethyl)-4,5-dimethoxy-benzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-bromo-2-(chloromethyl)-4,5-dimethoxy-benzene(54370-01-3)
• EPA Substance Registry System: 1-bromo-2-(chloromethyl)-4,5-dimethoxy-benzene(54370-01-3)

Safety Data

• Hazardous Substances Data: 54370-01-3(Hazardous Substances Data)

Usage

Appearance

White to off-white solid describes the physical form and color of the compound, which may vary slightly in shade.

Solubility

Insoluble in water, soluble in organic solvents refers to the compound's ability (or inability) to dissolve in different types of solvents, which can impact its applications and handling.

Uses

Intermediate in the synthesis of pharmaceuticals and agrochemicals indicates the compound's role as a precursor or building block in the production of various drugs and chemicals used in agriculture.

Reactivity

Possesses both bromine and chlorine atoms highlights the presence of these reactive halogens in the compound, which can participate in various chemical reactions and make it a versatile building block for creating other organic compounds.

Aromatic structure

A valuable compound for the development of new drugs and chemical products refers to the compound's aromatic nature, which can contribute to its stability and potential applications in medicinal chemistry and other fields.

Safety

Handle with care and follow proper safety protocols due to potential reactivity and toxicity emphasizes the importance of taking necessary precautions when working with this compound to minimize risks associated with its potential hazards.

InChI:InChI=1/C9H10BrClO2/c1-12-8-3-6(5-11)7(10)4-9(8)13-2/h3-4H,5H2,1-2H3

Upstream product

• 50-00-0 formaldehyd 
• 2859-78-1 4-Bromoveratrole 
• 54370-00-2 2-bromo-4,5-dimethoxybenzyl alcohol 
• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 5392-10-9 2-bromo-4,5-dimethoxybenzaldehyde 

Downstream Products

• 51655-39-1 2-bromo-4,5-dimethoxyphenylacetonitrile 
• 122323-02-8 2-(2-Bromo-4,5-dimethoxy-phenyl)-1-(2,3-dimethoxy-phenyl)-ethanone 
• 112378-02-6 8-benzyloxy-N-benzoyl-1-(2'-bromo-4',5'-dimethoxybenzyl)-1,2-dihydro-7-methoxyisoquinoline-1-carbonitrile 
• 52783-79-6 Diethyl-(2-brom-4.5-dimethoxy)-benzylacetamidomalonat 
• 859942-25-9 1,2-bis(2-bromo-4,5-dimethoxyphenyl)ethane 
• 299215-69-3 (E)-1,2-bis(2-bromo-4,5-dimethoxyphenyl)-N,N-dimethylethenylamine 
• 952196-37-1 1-(2-bromo-4,5-dimethoxybenzyl)-7,8-dimethoxy-3-methyl-1,2,4,5-tetrahydro-3H-3-benzazepin-2-one 
• 2292-20-8 Muramin 
• 656807-26-0 2-ethenyl-4,5-dimethoxybenzeneacetonitrile 
• 656807-33-9 2-ethenyl-4,5-dimethoxy-N-2-propenyl-benzeneethanamine 
• 656807-35-1 2-ethenyl-4,5-dimethoxy-N-3-butenyl-benzeneethanamine 
• 5963-51-9 1,2-bis(3,4-dimethoxyphenyl)ethane 
• 112378-03-7 8-benzyloxy-1-(2'-bromo-4',5'-dimethoxybenzyl)-7-methoxyisoquinoline 
• 112378-04-8 8-benzyloxy-1-(2'-bromo-4',5'-dimethoxybenzyl)-7-methoxy-N-methylisoquinolinium iodide 

Relevant articles and documents

NOVEL 6,7-DIHYDROPYRIDO[2,1-A]PHTHALAZIN-2-ONES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION

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PYRIDINE- AND PYRIMIDINECARBOXAMIDES AS CXCR2 MODULATORS

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2,3-DIHYDRO-1H-ISOINDOL-1-IMINE DERIVATIVES USEFUL AS THROMBIN PAR-1 RECEPTOR ANTAGONIST

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Pyridine- and Pyrimidinecarboxamides as CXCR2 Modulators

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TRISUBSTITUTED AMINE COMPOUNDS AS INHIBITORS OF -CHOLESTERYL ESTER TRANSFER PROTEIN CETP

The present invention relates to a compound of the general formula (1): (1)wherein, Y is a methylene group, and the like; A is an optionally substituted heterocyclic group, and the like; B is an optionally substituted phenyl group, and the like; R1 is an optionally substituted alkyl group, and the like; and R2 is an optionally substituted amino group, and the like; or a pharmaceutically acceptable derivative thereof, which has an inhibitory activity against cholesteryl ester transfer protein (CETP), thereby being useful for prophylaxis and/or treatment of arteriosclerotic diseases, hyperlipemia or dyslipidemia, and the like.

Determining the scope of the lanthanide mediated, sequential hydroamination/C-C cyclization reaction: Formation of tricyclic and tetracyclic aromatic nitrogen heterocycles

The scope of the lanthanide mediated, sequential hydroamination/C-C cyclization reaction was determined for the formation of tricyclic and tetracyclic aromatic nitrogen heterocycles. An array of ring sizes was explored to determine the diastereoselectivity. The electronic characteristics of the aromatic ring was also varied to determine how it affected the cascade reaction. It was found that the benzo[a]quinolizine and the pyrido[2,1,a]isoindolizine ring systems formed with the highest diastereoselectivity (>20:1), regardless of the electronic characteristics of the aromatic ring. Additionally, a tetracyclic indole nitrogen heterocycle was formed with a 2.3:1 diastereomeric ratio. A novel procedure for substrate preparation is also presented.

A Convenient Strategy for the Synthesis of 4,5-Bis(o-haloaryl)isoxazoles

A series of new 1,2-bis(o-haloaryl)ethanones is efficiently prepared and applied to the synthesis of 4,5-bis(o-haloaryl)isoxazoles. Isolation of intermediate hydroxyisoxazolines, which are structurally examined, provides a definitive proof for a heterocyclization mechanism based on an amine exchange process. The isolation and X-ray crystallographic studies of significant side products such as benzamides and triarylpropionitriles are also described.

Selective Preparation of Polycyclic Aromatic Hydrocarbons. Part 7. A Preparative Route to 10,11-Dihydro-5H-dibenzo-cycloheptenes Using Friedel-Crafts Intramolecular Cyclobenzylation

Cyclobenzylation of 2-hydroxymethyldiphenylethanes 4 and 2,2'-bis(hydroxymethyl)diphenylethanes 13 in the presence of a solid perfluorinated sulfonic acid resin, Nafion-H, as a catalyst results in novel polycyclic aromatic hydrocarbons, dibenzocyclopentenes.Dibenzocyclopentenes were also prepared from diphenylethanes by a benzylation reaction, which incorporates chloromethylation of a hydrocarbon followed by Friedel-Crafts intramolecular cyclization reaction.The present method involving the action of ClCH2OMe and TiCl4 on a variety of diphenylethanes (constructed such that electrophilic substitution occurs ortho to the diphenylethane linkage) offers a convenient, mild one-pot synthesis of substituted dibenzocycloheptenes.The mechanism of these reactions is also discussed.