54370-03-5

Basic information

• Product Name: 5-{2-[2-(3,4-dimethoxyphenyl)ethylamino]ethyl}-2-methoxyphenol
• Synonyms: 5-{2-[2-(3,4-dimethoxyphenyl)ethylamino]ethyl}-2-methoxyphenol
• CAS NO: 54370-03-5
• Molecular Weight: 331.412
• Mol File: 54370-03-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 5-{2-[2-(3,4-dimethoxyphenyl)ethylamino]ethyl}-2-methoxyphenol(CAS DataBase Reference)
• NIST Chemistry Reference: 5-{2-[2-(3,4-dimethoxyphenyl)ethylamino]ethyl}-2-methoxyphenol(54370-03-5)
• EPA Substance Registry System: 5-{2-[2-(3,4-dimethoxyphenyl)ethylamino]ethyl}-2-methoxyphenol(54370-03-5)

Safety Data

• Hazardous Substances Data: 54370-03-5(Hazardous Substances Data)

Upstream product

• 33710-70-2 N-(3-Hydroxy-4-methoxyphenethyl)-3.4-dimethoxyphenyl-acetamide 
• 120-20-7 2-(3,4-dimethoxyphenyl)-ethylamine 
• 75608-42-3 N-[2-(3,4-dimethoxyphenyl)ethyl]-2-(3-hydroxy-4-methoxyphenyl)acetamide 
• 54370-02-4 N-(3-Hydroxy-4-methoxy-phenaethyl)-2-(2-brom-4,5-dimethoxy-phenyl)-acetamid 
• 4697-62-5 6-bromohomoveratric acid 
• 51655-39-1 2-bromo-4,5-dimethoxyphenylacetonitrile 
• 54370-00-2 2-bromo-4,5-dimethoxybenzyl alcohol 
• 32042-14-1 N-[3-(benzyloxy)-4-methoxyphenethyl]-2-(2-bromo-4,5-dimethoxyphenyl)acetamide 
• 54370-01-3 1-bromo-2-(chloromethyl)-4,5-dimethoxy-benzene 

Downstream Products

• 1395084-83-9 C₂₀H₂₅NO₄ 

Relevant articles and documents

A new class of selective and potent 7-dehydrocholesterol reductase inhibitors

We prepared a number of N-phenethyltetrahydroisoquinolines structurally related to protoberberines. They were tested for activity against bacteria, fungi, and human leukemia HL-60 cells and also for inhibition of biosynthesis: ergosterol in yeasts and cholesterol in human cells. In the latter assay panel, several of the compounds were distinguished by a strong and selective inhibition of 7-dehydrocholesterol reductase (7-DHCR, EC 1.3.1.21), an enzyme responsible for the conversion of 7-dehydrocholesterol to cholesterol in the last step of cholesterol biosynthesis. In a whole-cell assay, the most active compound 5f showed a much stronger inhibition of overall cholesterol biosynthesis (IC 50 2.3 nM) than BM 15.766 (IC50 500 nM), presently the most selective known inhibitor of 7-DHCR. Since a defect of 7-dehydrocholesterol reductase is associated with Smith-Lemli-Opitz syndrome (SLOS), the potent and selective inhibitors reported here will enable more detailed investigation of the pathogenesis of SLOS.