5438-22-2

Usage

Uses

Used in Pharmaceutical Industry:
3-(ETHOXYCARBONYL)-4,4-DIPHENYL-3-BUTENOIC ACID is used as a key intermediate in the synthesis of various pharmaceuticals. Its unique structure allows it to be a versatile component in the development of new drugs, contributing to the advancement of medicinal chemistry.
Used in Fine Chemicals Production:
In the fine chemicals sector, 3-(ETHOXYCARBONYL)-4,4-DIPHENYL-3-BUTENOIC ACID is utilized as a fundamental component in the production of specialty chemicals. Its presence in these compounds is crucial for achieving desired properties and performance characteristics.
Used in Material Science:
3-(ETHOXYCARBONYL)-4,4-DIPHENYL-3-BUTENOIC ACID also finds application in material science, where it is employed to develop new materials with specific properties. Its integration into material compositions can lead to innovations in various material technologies.
Overall, 3-(ETHOXYCARBONYL)-4,4-DIPHENYL-3-BUTENOIC ACID is a significant chemical in the industry due to its wide-ranging applications in medicinal chemistry, drug discovery, and material science, making it an indispensable component in the synthesis of a variety of products.

InChI:InChI=1/C19H18O4/c1-2-23-19(22)16(13-17(20)21)18(14-9-5-3-6-10-14)15-11-7-4-8-12-15/h3-12H,2,13H2,1H3,(H,20,21)

Upstream product

• 119-61-9 benzophenone 
• 865-47-4 potassium tert-butylate 
• 75-65-0 tert-butyl alcohol 
• 123-25-1 succinic acid diethyl ester 
• 157494-69-4 methyl 3-ethoxycarbonyl-4,4-diphenyl-3-butenoate 
• 64-17-5 ethanol 

Downstream Products

• 7746-94-3 5,5-diphenyldihydrofuran-2(3H)-one 
• 7498-88-6 4,4-diphenylbut-3-enoic acid 
• 47126-79-4 2-benzhydryl succinic acid 
• 23242-87-7 3-bromo-5-oxo-2,2-diphenyl-tetrahydro-furan-3-carboxylic acid ethyl ester 
• 78250-28-9 ethyl 4-acetoxy-1-phenyl-2-naphthoate 
• 81756-93-6 ethyl 1-oxo-3-phenyl-2-indenylacetate 
• 99055-09-1 4,4-Diphenyl-3-aethoxycarbonyl-buttersaeure 
• 157494-69-4 methyl 3-ethoxycarbonyl-4,4-diphenyl-3-butenoate 
• 79219-83-3 2-Benzhydrylidene-3-[1-phenyl-meth-(E)-ylidene]-succinic acid 
• 79219-69-5 2-Benzhydrylidene-3-[1-(4-methoxy-phenyl)-meth-(E)-ylidene]-succinic acid 
• 91231-49-1 3-Benzhydrylidene-4-[1-(4-nitro-phenyl)-meth-(E)-ylidene]-dihydro-furan-2,5-dione 
• 91231-61-7 3-Benzhydrylidene-4-[1-(4-methoxy-phenyl)-meth-(E)-ylidene]-dihydro-furan-2,5-dione 
• 37460-00-7 (E)-benzylidene(diphenylmethylene)succinic anhydride 
• 472964-95-7 2-Benzhydrylidene-3-[1-p-tolyl-meth-(E)-ylidene]-succinic acid 

Relevant academic research and scientific papers

Benzophenone substituted fulgide photochromic compound and preparation method thereof

The invention discloses a benzophenone substituted fulgide photochromic compound and a preparation method thereof. According to the preparation method, diethyl succinate is used as a core skeleton, 4-pyridine methylene is grafted to the 2-position of diet

Substituent effects on the photochromic properties of 3,3-diphenyspiro[benzofluorenopyran-cyclopentaphenanthrene]s

The introduction of electron-donating groups on the skeleton of a naphthopyran, 3,3-diphenyspiro[benzofluorenopyran-cyclopentaphenanthrene], has led to the development of a photochromic dye applicable to photochromic lenses. Introducing a methoxy group to C6 moved the absorption band of the MC form towards the longer wavelength. Further introduction of methoxy groups to the para-position of the phenyl groups on C3 induced faster decoloration of the MC form. Additional introduction of a methoxy group to C13 led to the enhancement of the absorption intensity as well as the facile, economic synthesis of the dye caused by the symmetrical property of the starting material.

Inhibition of activated STAT5 in Bcr/Abl expressing leukemia cells with new pimozide derivatives

STATs are transcription factors acting as intracellular signaling after stimulation with cytokines, growth factors and hormones. STAT5 is also constitutively active in many forms of cancers, including chronic myelogenous leukemia, acute lymphoblastic leukemia and Hodgkin's lymphoma. Recently, literature reported that the neuroleptic drug pimozide inhibits STAT5 phosphorylation inducing apoptosis in CML cells. We undertook an investigation from pimozide structure, obtaining simple derivatives with cytotoxic and STAT5-inhibitory activity, two of them markedly more potent than pimozide.

Stereoselective Stobbe condensation of ethyl methyl diphenylmethylenesuccinate with aromatic aldehydes

(matrix presented) The E configuration of benzylidene(diphenylmethylene)succinic anhydride (R = H), obtained by the Stobbe condensation of ethyl methyl diphenylmethylenesuccinate with benzaldehyde, was determined by single-crystal X-ray diffraction. Nonco

Novel Regioselective Ester Hydrolysis by Pig-Liver Esterase

Pig-liver esterase, which catalyzed the hydrolysis of substrates containing both saturated and αβ-unsaturated/cyclopropanecarboxylic esters (methyl and ethyl), was studied. An exclusive hydrolysis of the saturated esters was observed. Kinetic experiments revealed that the presence of deactivated carbonyl in the unsaturated/cyclopropanecarboxylic esters and their weaker bindings are both responsible for the observed specificity. The relative binding abilities of the substrates have been explained in light of Jones active-site model. The regioselectivity has been exploited in the synthesis of intermediates for the thromboxane synthetase inhibitor.

Furan-2(3H)- and 2(5H)-ones. Part 5. Photoreaction of 3-Benzylfuran-2(5H)-ones; Cyclisation to Indenofuranones

The effect of substitution at the 'central methane' on the photoreactivity of 3-benzylfuran-2(5H)-ones 5a-g was investigated.Despite its di-?-methane structure, photochemical arylation was effected to give substituted indenofuranones 6 in good yields.Only