543906-20-3Relevant articles and documents
AFQ056/mavoglurant, a novel clinically effective mGluR5 antagonist: Identification, SAR and pharmacological characterization
Vranesic, Ivo,Ofner, Silvio,Flor, Peter Josef,Bilbe, Graeme,Bouhelal, Rochdi,Enz, Albert,Desrayaud, Sandrine,McAllister, Kevin,Kuhn, Rainer,Gasparini, Fabrizio
, p. 5790 - 5803 (2014)
Here we describe the identification, structure-activity relationship and the initial pharmacological characterization of AFQ056/mavoglurant, a structurally novel, non-competitive mGlu5 receptor antagonist. AFQ056/mavoglurant was identified by chemical der