54397-10-3

Upstream product

• 30298-36-3 2-mercaptothioacetic acid 
• 2362-79-0 N-(4-chlorobenzylidene)aniline 
• 68-11-1 mercaptoacetic acid 
• 1613-95-2 (E)-1-(4-chlorophenyl)-N-phenylmethanimine 
• 104-88-1 4-chlorobenzaldehyde 
• 623-51-8 ethyl 2-sulfanylacetate 
• 62-53-3 aniline 
• 622-37-7 Phenyl azide 

Downstream Products

• 78830-95-2 2-(4-chlorophenyl)-3-phenyl-4-oxothiazolidine 1-oxide 
• 130887-93-3 2-(4-chlorophenyl)-3-phenyl-5-phenylmethylene-4-oxo-1,3-thiazolidine 
• 130887-96-6 2-(4-chlorophenyl)-3-phenyl-5-phenylmethylene-4-oxo-1,3-thiazolidine-1-oxide 
• 130888-01-6 2-(4-chlorophenyl)-3-phenyl-5-diphenylmethyl-4-oxo-1,3-thiazolidine-1-oxide 
• 54397-12-5 2-(4-chloro-phenyl)-5-(4-dimethylamino-benzylidene)-3-phenyl-thiazolidin-4-one 

Relevant academic research and scientific papers

Preparation of thiazolidin-4-one derivatives using ZnO–NiO–NiFe2O4 nano-composite system

The hydrothermal synthesis of ZnO–NiO–NiFe2O4 nano-composite is reported. The sample was utilized to characterize via XRD, FE-SEM, EDS, FT-IR, UV–Vis, and BET techniques. The sample consisted of three different phases as ZnO (hexagonal), NiO (cubic), and NiFe2O4 (cubic) with the average particle size as 34?nm and specific surface area, average pore diameter, and pore volume as 64.35?m2?g?1, 13.02?nm, and 0.201?cm3?g?1, respectively. Catalytic behavior of the nano-composite was investigated on the synthesis of thiazolidin-4-one derivatives under thermal and ultrasonic irradiation condition. Our results show that the catalytic activity of ZnO–NiO–NiFe2O4 nano-composite is much higher than ZnO, NiO, and NiFe2O4 metal oxides. All products were prepared in high yields with short reaction times. In addition, the catalyst was recovered for at least five times.

Visible-light-promoted C[sbnd]N and C[sbnd]S bonds formation: A catalyst and solvent-free photochemical approach for the synthesis of 1,3-thiazolidin-4-ones

A visible-light-induced, one-pot mild and efficient, multicomponent-tandem synthesis of diversified 1,3-thiazolidin-4-ones under catalyst and solvent-free conditions is reported. Here, visible-light, an ideal source of energy, has been used as photochemic

Silica chloride (SiO2-Cl) catalyzed one pot synthesis of 2,3-disubstituted-thiazolidin-4-one

In this paper, we report one-pot, three-component cyclo condensation of an aldehyde, an amine and thioglycolic acid to form 2,3-disubstituted-thiazolidin-4-one by using supported protic acid (Silica Chloride: SiO2-Cl) catalyst. The catalyst SiO2-Cl is compatible with a variety of aldehydes (aryl/heteroaryl) and the aromatic amines affording 2,3-disubstituted-thiazolidin-4-one analogs in 72–89% yields. Moreover, the supported catalyst was recycled several times without significant loss of catalytical activity.

Tromethamine organocatalyzed efficient tandem-multicomponent synthesis of new thiazolyl-4-thiazolidinones in aqueous medium

The catalytic potential of tris(hydroxymethyl)aminomethane (Tromethamine) has been assessed for the one pot three component tandem reaction involving a thiazolylmethoxy phenyl/aromatic carboxaldehyde, substituted amines and thioglycolic acid to form new t

TS-1 zeolite as a Lewis acid catalyst for solvent-free one-pot synthesis of 1,3-thiazolidin-4-ones

Abstract: Titanium silicate (TS-1) zeolite heterogeneous catalyst is synthesized by the hydrothermally discontinuous method and is characterized by using XRD, SEM, TEM, and NH3–TPD techniques. The catalytic activity of the TS-1 type zeolite was tested for one-pot solvent-free synthesis of 1,3-thiazolidine-4-ones. The present technique illustrates many benefits, including eco-friendly reaction conditions, environmentally helpful, short response time, simplicity, straightforward separatation, catalyst reusability and high yields of the products. Furthermore, the catalyst was utilized for four recycle reactions and it has been found that the catalyst shows consistent chemical process activity. Graphical abstract: [Figure not available: see fulltext.].

Graphene oxide catalyzed C-N/C-S/[3+2] cyclization cascade for green synthesis of thiazolidinone in water

In this paper, first graphene oxide catalyzed one-pot three-component green synthesis of 1,3- thiazolidin-4-one using amine, aldehyde and mercapto acetic acid in water has been reported. The reaction is affected via sequential C-N and C-S bond formation a

Ultrasound assisted, VOSO4 catalyzed synthesis of 4-thiazolidinones: Antimicrobial evaluation of indazole-4-thiazolidinone derivatives

A simple and expedient multicomponent protocol was developed to synthesize 4-thiazolidinones by employing VOSO4 as a catalyst under ultrasonic irradiation. The significant features of this protocol includes shorter reaction time, high yields, low catalyst loading, and also the catalyst can be recovered and reused up to next four cycles without significant loss in catalytic activity. All the synthesized novel indazole compounds were evaluated for their antibacterial and anti-biofilm activities. Compounds 9n, 9o and 9q showed promising activity (MIC value of 3.9 μg/mL) against K. planticola (MTCC 530). They also exhibited significant bactericidal activity against K. planticola (MTCC 530) (MBC value of 15.6 μg/mL). Additionally, 9n, 9o and 9q inhibited biofilm formation (IC50 values ranging between 20.28–20.79 μg/mL) in this organism.

A catalysis study of mesoporous MCM-41 supported Schiff base and CuSO4·5H2O in a highly regioselective synthesis of 4-thiazolidinone derivatives from cyclocondensation of mercaptoacetic acid

Mesoporous MCM-41 supported Schiff base and CuSO4·5H2O shows high catalytic activity in the cyclocondensation of mercaptoacetic acid with imines (or aldehydes and amines) to afford pharmaceutically important thiazolidinone derivatives. The catalytic reactions involving two-components or three-components afforded the desired product in high yields (up to 98% and 99%). Moreover, the catalyst works well with respect to recyclability, giving the product in 85% and 83% yields after recycling six times.

Facile synthesis of 1,3-thiazolidin-4-ones as antitubercular agents

We have developed, highly efficient, one-pot, solvent-free, [Et3NH][HSO4] catalyzed multicomponent reaction protocol for the synthesis of 1,3-thiazolidin-4-ones in excellent yields. For the first time, the 1,3-thiazolidin-4-ones were evaluated in vitro for their antimycobacterial activity against Mycobacterium tuberculosis dormant MTB H37Ra and Mycobacterium bovis BCG strains. Among the synthesized basic 1,3-thiazolidin-4-ones, particularly the compounds 4c, 4d, 4e, 4f, 4h, 4i and 4j displays promising antitubercular activity along with no significant cytotoxicity against the cell lines MCF-7, A549 and HCT-116.

Preparation and characterization of Fe3O4@SiO2/APTPOSS core–shell composite nanomagnetics as a novel family of reusable catalysts and their application in the one-pot synthesis of 1,3-thiazolidin-4-one derivatives

Octakis[3-(3-aminopropyltriethoxysilane)propyl]octasilsesquioxane (APTPOSS) as a polyhedral oligomeric silsesquioxane derivative was prepared and used as a pioneer reagent to obtain a novel core–shell composite using magnetic iron oxide nanoparticles as t