54409-17-5Relevant academic research and scientific papers
Heterogeneous gold(III)-catalyzed tandem cyclization of 2-alkynylbenzamides with ammonium acetate toward 1-aminoisoquinolines
Yang, Weisen,Du, Yingying,Yi, Feiyan,Cai, Mingzhong
, p. 34 - 41 (2020/06/05)
Heterogeneous tandem cyclization of 2-alkynylbenzamides with ammonium acetate is achieved in acetonitrile at 85 °C using a magnetic nanoparticles-immobilized bipy-gold(III) complex and AgSbF6 as catalysts to afford a variety of 1-aminoisoquinoline derivatives in moderate to high yields. This heterogeneous gold catalyst can be easily recovered from the reaction mixture by simply applying an external magnetic field and can be recycled at least seven times without any apparent loss of catalytic activity.
Nickel-Catalyzed Tandem Reaction of Functionalized Arylacetonitriles with Arylboronic Acids in 2-MeTHF: Eco-Friendly Synthesis of Aminoisoquinolines and Isoquinolones
Zhen, Qianqian,Chen, Lepeng,Qi, Linjun,Hu, Kun,Shao, Yinlin,Li, Renhao,Chen, Jiuxi
supporting information, p. 106 - 111 (2019/12/11)
The first example of the nickel-catalyzed tandem addition/cyclization of 2-(cyanomethyl)benzonitriles with arylboronic acids in 2-MeTHF has been developed, which provides the facile synthesis of aminoisoquinolines with good functional group tolerance under mild conditions. This chemistry has also been successfully applied to the synthesis of isoquinolones by the tandem reaction of methyl 2-(cyanomethyl)benzoates with arylboronic acids. The use of the bio-based and green solvent 2-MeTHF as the reaction medium makes the synthesis process environmentally benign. The synthetic utility of this chemistry is also indicated by the synthesis of biologically active molecules.
Regioselective Access to 3-Aryl-1-aminoisoquinolines via Nickel(I)-Catalyzed C-C and C-N Cascade Coupling Reactions from the Substituted 2-(Cyanomethyl)benzonitriles
Yang, Xicheng,Yu, Haihua,Xu, Yulong,Shao, Liming
, p. 9682 - 9695 (2018/09/06)
A novel and regioselective Ni(I) catalyzed C-C and C-N cascade coupling reactions has been developed. The cascade furnishes atom-economic access to 40 3-aryl-1-aminoisoquinolines. The regioselectivity of C(sp3)-cyano group over C(sp2
Synthesis of 1-aminoisoquinolines by gold(III)-mediated domino reactions from 2-alkynylbenzamides and ammonium acetate
Long, Yuhua,She, Zhigang,Liu, Xiaochen,Chen, Yu
, p. 2579 - 2588 (2013/04/24)
A facile synthetic route toward pharmaceutically interesting 1-aminoisoquinoline derivatives by gold(III)-mediated domino reactions is described. This synthetic protocol starts from readily available 2-alkynylbenzamides and ammonium acetate and takes plac
