1207252-50-3

Upstream product

• 3930-83-4 o-iodobenzamide 
• 4001-73-4 2-Bromobenzamide 

Downstream Products

• 13307-67-0 ethyl 1H-indole-1-carboxylate 
• 491-30-5 1-isoquinolone 
• 69643-92-1 (Z)-3-(2-(4-chlorophenyl)-2-oxoethylidene)isoindolin-1-one 
• 69643-73-8 (3Z)-3-(2-oxo-2-phenylethylidene)-2,3-dihydro-1H-isoindol-1-one 
• 85301-70-8 3-amino-2-benzoyl-1H-inden-1-one 
• 1425605-52-2 methyl 4-((2-carbamoylphenyl)ethynyl)benzoate 
• 1425605-50-0 2-((4-(trifluoromethyl)phenyl)ethynyl)benzamide 
• 25407-16-3 2-(naphthalen-1-ylethynyl)benzamide 
• 1425605-90-8 methyl 4-(1-aminoisoquinolin-3-yl)benzoate 
• 1425605-88-4 3-(4-(trifluoromethyl)phenyl)isoquinolin-1-amine 
• 54409-17-5 3-(naphthalen-1-yl)isoquinolin-1-amine 
• 1208108-43-3 C₁₉H₂₀ClN₅O₄ 
• 148550-52-1 ethyl N-(2-ethynylphenyl)carbamate 
• 1337988-27-8 ethyl 4-oxo-2-p-tolyl-3,4-dihydroquinoline-1(2H)-carboxylate 

Relevant academic research and scientific papers

Synthesis of 3-Alkylideneisoindolin-1-ones via Sonogashira Cyclocarbonylative Reactions of 2-Ethynylbenzamides

Cyclocarbonylative Sonogashira reactions of ortho-ethynylbenzamides have been investigated. The process is carried out under CO pressure, in the presence of a very small amount of PdCl2(PPh3)2 (0.4 mol %) as a catalytic precursor and without the need for

Regio- and Stereoselective Synthesis of Isoindolin-1-ones through BuLi-Mediated Iodoaminocyclization of 2-(1-Alkynyl)benzamides

A simple and straightforward synthesis of isoindolin-1-ones is reported. Exclusive N-cyclization of the amide functional group, an ambident nucleophile, was accomplished for the cyclization of 2-(1-alkynyl)benzamides using n-BuLi-I2/ICl. The methodology works with the primary amide and affords the desired isoindolinones in yields of 38-94%. Interestingly, the isolated products exhibit a Z-stereochemistry across the C=C double bond. The reaction mechanism involving the formation of either a vinylic anion or an intimate ion pair intermediate is proposed.

Synthesis of 1-aminoisoquinolines by gold(III)-mediated domino reactions from 2-alkynylbenzamides and ammonium acetate

A facile synthetic route toward pharmaceutically interesting 1-aminoisoquinoline derivatives by gold(III)-mediated domino reactions is described. This synthetic protocol starts from readily available 2-alkynylbenzamides and ammonium acetate and takes plac

Formation of indoles, dihydroisoquinolines, and dihydroquinolines by ruthenium-catalyzed heterocyclizations

Indoles, dihydroisoquinolines, and dihydroquinolines were efficiently prepared by ruthenium-catalyzed heterocyclizations of aromatic homo- and bis-homopropargyl amines/amides in the presence of an amine/ammonium base-acid pair. These regioselective 5-endo and 6-endo cyclizations most probably occur by nucleophilic trapping of key ruthenium-vinylidene intermediates. Georg Thieme Verlag Stuttgart · New York.

Ruthenium-catalyzed cycloisomerization of aromatic homo- and bis-homopropargylic amines/amides: Formation of indoles, dihydroisoquinolines and dihydroquinolines

Ruthenium-catalyzed cycloisomerizations of aromatic homo- and bis-homopropargylic amines/amides efficiently afford indoles, dihydroisoquinolines and dihydroquinolines. These processes were regioselective (5- and 6-endo cyclizations) on using key Ru vinylidene intermediates. The presence of an amine/ammonium base-acid pair increased the rate of cyclization and facilitated the catalytic turnover. Copyright