54409-76-6

Upstream product

• 505-18-0 2,3,4,5-tetrahydropyridine 
• 108-56-5 diethyl oxaloacetate 

Downstream Products

• 1046471-59-3 C₁₆H₁₇FN₂O₃ 
• 1429292-10-3 N-(3-(3,4-dichlorophenyl)propyl)-2-hydroxy-3-oxo-3,5,6,7,8,8a-hexahydroindolizine-1-carboxamide 
• 1429293-56-0 N-(3-(3,4-dichlorophenyl)propyl)-2-methoxy-3-oxo-3,5,6,7,8,8a-hexahydroindolizine-carboxamide 

Relevant academic research and scientific papers

4-Hydroxy-5-pyrrolinone-3-carboxamide HIV-1 integrase inhibitors

The viral enzyme integrase is essential for the replication of HIV-1 and, after the discovery of Isentress, represents a validated target for anti-retroviral therapy. Incorporation of the dihydroxycarbonyl pharmacophore into a pyrrolinone scaffold led to the discovery of 5-pyrrolinone-3-carboxamides as a structurally diverse class of HIV-1 integrase inhibitors.