Welcome to LookChem.com Sign In|Join Free

CAS

  • or

108-56-5

Post Buying Request

108-56-5 Suppliers

Recommended suppliersmore

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier

108-56-5 Usage

Chemical Properties

Colorless liquid

Uses

Diethyl Oxalacetate is an allosteric inhibitor of human m-NAD(P)-ME.

Check Digit Verification of cas no

The CAS Registry Mumber 108-56-5 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 1,0 and 8 respectively; the second part has 2 digits, 5 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 108-56:
(5*1)+(4*0)+(3*8)+(2*5)+(1*6)=45
45 % 10 = 5
So 108-56-5 is a valid CAS Registry Number.
InChI:InChI=1/C8H12O5/c1-3-12-7(10)5-6(9)8(11)13-4-2/h3-5H2,1-2H3

108-56-5 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
  • Packaging
  • Price
  • Detail
  • TCI America

  • (O0073)  Diethyl Oxalacetate  >95.0%(GC)

  • 108-56-5

  • 5g

  • 940.00CNY

  • Detail
  • TCI America

  • (O0073)  Diethyl Oxalacetate  >95.0%(GC)

  • 108-56-5

  • 25g

  • 2,760.00CNY

  • Detail

108-56-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 10, 2017

Revision Date: Aug 10, 2017

1.Identification

1.1 GHS Product identifier

Product name Diethyl Oxalacetate

1.2 Other means of identification

Product number -
Other names Diethyl 2-oxosuccinate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:108-56-5 SDS

108-56-5Synthetic route

sodium 1,4-diethoxy-1,4-dioxobut-2-en-2-olate
40876-98-0, 88330-76-1, 125898-38-6

sodium 1,4-diethoxy-1,4-dioxobut-2-en-2-olate

diethyl oxaloacetate
108-56-5

diethyl oxaloacetate

Conditions
ConditionsYield
With hydrogenchloride In diethyl ether; water83%
ethyl acetate
141-78-6

ethyl acetate

oxalic acid diethyl ester
95-92-1

oxalic acid diethyl ester

diethyl oxaloacetate
108-56-5

diethyl oxaloacetate

Conditions
ConditionsYield
Stage #1: oxalic acid diethyl ester With sodium ethanolate In benzene at 0℃; Inert atmosphere;
Stage #2: ethyl acetate In benzene at 0 - 20℃; for 14.5h; Inert atmosphere;
74%
With diethyl ether; sodium ethanolate Behandeln in Wasser mit verduennter Schwefelsaeure in Gegenwart von Aether;
With diethyl ether; sodium Behandeln in Wasser mit verduennter Schwefelsaeure in Gegenwart von Aether;
acetylenedicarboxylic acid diethyl ester
762-21-0

acetylenedicarboxylic acid diethyl ester

diethyl oxaloacetate
108-56-5

diethyl oxaloacetate

Conditions
ConditionsYield
With water; platinum(II) chloride In methanol at 60℃;42%
Ketene
463-51-4

Ketene

oxalyl dichloride
79-37-8

oxalyl dichloride

diethyl oxaloacetate
108-56-5

diethyl oxaloacetate

Conditions
ConditionsYield
With chloroform at 65℃; Behandeln des Reaktionsprodukts mit Aethanol.;
Acetoxymaleinsaeureanhydrid
19064-79-0

Acetoxymaleinsaeureanhydrid

ethanol
64-17-5

ethanol

A

ethyl acetate
141-78-6

ethyl acetate

B

diethyl oxaloacetate
108-56-5

diethyl oxaloacetate

Acetoxymaleinsaeureanhydrid
19064-79-0

Acetoxymaleinsaeureanhydrid

ethanol
64-17-5

ethanol

diethyl oxaloacetate
108-56-5

diethyl oxaloacetate

diethylitaconate
2409-52-1

diethylitaconate

diethyl oxaloacetate
108-56-5

diethyl oxaloacetate

Conditions
ConditionsYield
bei der Ozonspaltung;
diethyl ether
60-29-7

diethyl ether

sodium ethanolate
141-52-6

sodium ethanolate

ethyl acetate
141-78-6

ethyl acetate

oxalic acid diethyl ester
95-92-1

oxalic acid diethyl ester

diethyl oxaloacetate
108-56-5

diethyl oxaloacetate

ethanol
64-17-5

ethanol

sodium ethanolate
141-52-6

sodium ethanolate

ethyl acetate
141-78-6

ethyl acetate

oxalic acid diethyl ester
95-92-1

oxalic acid diethyl ester

diethyl oxaloacetate
108-56-5

diethyl oxaloacetate

Ketene
463-51-4

Ketene

chloroform
67-66-3

chloroform

Ethyl oxalyl chloride
4755-77-5

Ethyl oxalyl chloride

A

4,6-dioxo-5,6-dihydro-4H-pyran-2-carboxylic acid ethyl ester
108153-39-5

4,6-dioxo-5,6-dihydro-4H-pyran-2-carboxylic acid ethyl ester

B

oxalic acid diethyl ester
95-92-1

oxalic acid diethyl ester

C

diethyl oxaloacetate
108-56-5

diethyl oxaloacetate

Conditions
ConditionsYield
anschliessenden Erwaermen mit Aethanol;
Ketene
463-51-4

Ketene

Ethyl oxalyl chloride
4755-77-5

Ethyl oxalyl chloride

diethyl oxaloacetate
108-56-5

diethyl oxaloacetate

Conditions
ConditionsYield
With sulfur dioxide at 65℃; Behandeln des Reaktionsprodukts mit Aethanol.;
sodium ethanolate
141-52-6

sodium ethanolate

oxalic acid diethyl ester
95-92-1

oxalic acid diethyl ester

3-ethoxycarbonyl-3-penten-2-one
15301-37-8, 67556-07-4, 67556-08-5

3-ethoxycarbonyl-3-penten-2-one

A

hydroxy-terephthalic acid diethyl ester
74744-72-2

hydroxy-terephthalic acid diethyl ester

B

diethyl oxaloacetate
108-56-5

diethyl oxaloacetate

oxalic acid diethyl ester
95-92-1

oxalic acid diethyl ester

3-ethoxycarbonyl-3-penten-2-one
15301-37-8, 67556-07-4, 67556-08-5

3-ethoxycarbonyl-3-penten-2-one

A

hydroxy-terephthalic acid diethyl ester
74744-72-2

hydroxy-terephthalic acid diethyl ester

B

diethyl oxaloacetate
108-56-5

diethyl oxaloacetate

Conditions
ConditionsYield
With ethanol; sodium ethanolate
Dichlormethylenbrenztraubensaeureaethylester; Dichlorvinylglyoxylsaeureaethylester
16493-86-0

Dichlormethylenbrenztraubensaeureaethylester; Dichlorvinylglyoxylsaeureaethylester

sodium ethanolate
141-52-6

sodium ethanolate

diethyl oxaloacetate
108-56-5

diethyl oxaloacetate

Conditions
ConditionsYield
In ethanol
2-[(E)-1-Methyl-2-phenyl-ethylimino]-succinic acid diethyl ester
87670-07-3

2-[(E)-1-Methyl-2-phenyl-ethylimino]-succinic acid diethyl ester

A

dexamfetamine
51-64-9

dexamfetamine

B

l-amphetamine
156-34-3

l-amphetamine

C

diethyl oxaloacetate
108-56-5

diethyl oxaloacetate

Conditions
ConditionsYield
With sulfuric acid In water for 2h; Ambient temperature; Yield given;
2-[(E)-1-Phenyl-ethylimino]-succinic acid diethyl ester
87670-11-9

2-[(E)-1-Phenyl-ethylimino]-succinic acid diethyl ester

A

(S)-1-phenyl-ethylamine
2627-86-3

(S)-1-phenyl-ethylamine

B

(R)-1-phenyl-ethyl-amine
3886-69-9

(R)-1-phenyl-ethyl-amine

C

diethyl oxaloacetate
108-56-5

diethyl oxaloacetate

Conditions
ConditionsYield
With sulfuric acid In water for 2h; Ambient temperature; Yield given;
itaconic acid ethyl ester

itaconic acid ethyl ester

diethyl oxaloacetate
108-56-5

diethyl oxaloacetate

Conditions
ConditionsYield
Ozonolyse;
Ketene
463-51-4

Ketene

Ethyl oxalyl chloride
4755-77-5

Ethyl oxalyl chloride

liquid sulfur dioxide

liquid sulfur dioxide

diethyl oxaloacetate
108-56-5

diethyl oxaloacetate

Conditions
ConditionsYield
anschliessenden Behandeln mit Aethanol;
diethyl ether
60-29-7

diethyl ether

ethyl acetate
141-78-6

ethyl acetate

oxalic acid diethyl ester
95-92-1

oxalic acid diethyl ester

sodium

sodium

diethyl oxaloacetate
108-56-5

diethyl oxaloacetate

ethanol
64-17-5

ethanol

sodium ethanolate
141-52-6

sodium ethanolate

ethyl acetate
141-78-6

ethyl acetate

oxalic acid diethyl ester
95-92-1

oxalic acid diethyl ester

A

diethyl oxaloacetate
108-56-5

diethyl oxaloacetate

B

oxalcitric acid lactonetriethyl ester

oxalcitric acid lactonetriethyl ester

C

α-pyrone-tricarboxylic acid-(4.5.6)-triethyl ester

α-pyrone-tricarboxylic acid-(4.5.6)-triethyl ester

diethyl ether
60-29-7

diethyl ether

ethyl acetate
141-78-6

ethyl acetate

oxalic acid diethyl ester
95-92-1

oxalic acid diethyl ester

sodium

sodium

A

diethyl oxaloacetate
108-56-5

diethyl oxaloacetate

B

oxalcitric acid lactonetriethyl ester

oxalcitric acid lactonetriethyl ester

C

α-pyrone-tricarboxylic acid-(4.5.6)-triethyl ester

α-pyrone-tricarboxylic acid-(4.5.6)-triethyl ester

Ketene
463-51-4

Ketene

oxalyl dichloride
79-37-8

oxalyl dichloride

liquid sulfur dioxide

liquid sulfur dioxide

A

3,4-dioxo-hexanedicarboxylic acid diethyl ester
3249-69-2

3,4-dioxo-hexanedicarboxylic acid diethyl ester

B

diethyl oxaloacetate
108-56-5

diethyl oxaloacetate

Conditions
ConditionsYield
Behandeln des Reaktionsprodukts mit Aethanol;
ethanol
64-17-5

ethanol

imino-succinic acid diethyl ester
52604-04-3

imino-succinic acid diethyl ester

copper diacetate
142-71-2

copper diacetate

acetic acid
64-19-7

acetic acid

A

ammonia
7664-41-7

ammonia

B

diethyl oxaloacetate
108-56-5

diethyl oxaloacetate

acetoxy-hydroxy-fumaric acid diethyl ester
114352-39-5

acetoxy-hydroxy-fumaric acid diethyl ester

air

air

aqueous solutions of pH > 11

aqueous solutions of pH > 11

A

oxalic acid
144-62-7

oxalic acid

B

diethyl oxaloacetate
108-56-5

diethyl oxaloacetate

hydrogenchloride
7647-01-0

hydrogenchloride

bis-(1,2-bis-ethoxycarbonyl-ethylidene)-guanidine

bis-(1,2-bis-ethoxycarbonyl-ethylidene)-guanidine

A

guanidine nitrate
113-00-8

guanidine nitrate

B

diethyl oxaloacetate
108-56-5

diethyl oxaloacetate

bis-(1,2-bis-ethoxycarbonyl-ethylidene)-guanidine

bis-(1,2-bis-ethoxycarbonyl-ethylidene)-guanidine

ammonia
7664-41-7

ammonia

A

guanidine nitrate
113-00-8

guanidine nitrate

B

diethyl oxaloacetate
108-56-5

diethyl oxaloacetate

3-cyano-propene-1,2,3-tricarboxylic acid triethyl ester

3-cyano-propene-1,2,3-tricarboxylic acid triethyl ester

ethyl acetate
141-78-6

ethyl acetate

A

glyoxylic acid ethyl ester
924-44-7

glyoxylic acid ethyl ester

B

diethyl oxaloacetate
108-56-5

diethyl oxaloacetate

C

oxalcyanoacetic acid diethyl ester

oxalcyanoacetic acid diethyl ester

Conditions
ConditionsYield
man erhaelt der Oxalessigester infolge des α-Cyan-aconitsaeure-triaethylester-Gehalts;
L-aspartic acid diethyl ester
13552-87-9

L-aspartic acid diethyl ester

A

diethyl oxaloacetate
108-56-5

diethyl oxaloacetate

B

bromoethoxycarbonylmethylene-4-nitro-phenylhydrazine

bromoethoxycarbonylmethylene-4-nitro-phenylhydrazine

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: benzene / 72 h / Heating
2: H2 / 5percent palladium on charcoal / ethanol / 16 h / Ambient temperature
3: tert-butyl hypochlorite / diethyl ether / 0.5 h / 0 °C
4: sodium ethoxide / ethanol / 1 h / 40 °C
5: 5percent sulfuric acid / H2O / 2 h / Ambient temperature
View Scheme
Multi-step reaction with 5 steps
1: benzene / 48 h / Heating
2: H2 / 5percent palladium on charcoal / ethanol / 16 h / Ambient temperature
3: tert-butyl hypochlorite / diethyl ether / 0.5 h / 0 °C
4: sodium ethoxide / ethanol / 1 h / 40 °C
5: 5percent sulfuric acid / H2O / 2 h / Ambient temperature
View Scheme

A

diethyl oxaloacetate
108-56-5

diethyl oxaloacetate

B

bromoethoxycarbonylmethylene-4-nitro-phenylhydrazine

bromoethoxycarbonylmethylene-4-nitro-phenylhydrazine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sodium ethoxide / ethanol / 1 h / 40 °C
2: 5percent sulfuric acid / H2O / 2 h / Ambient temperature
View Scheme
aminopyridin-2-ylacetic acid ethyl ester
55243-15-7

aminopyridin-2-ylacetic acid ethyl ester

diethyl oxaloacetate
108-56-5

diethyl oxaloacetate

ethyl 3-(1'-ethoxycarbonylimidazo<1,5-a>pyrid-3'-yl)-2-oxopropionate

ethyl 3-(1'-ethoxycarbonylimidazo<1,5-a>pyrid-3'-yl)-2-oxopropionate

Conditions
ConditionsYield
for 7h; Heating;8%
acetamidine
143-37-3

acetamidine

diethyl oxaloacetate
108-56-5

diethyl oxaloacetate

ethyl 2-methyl-6-oxo-1H-pyrimidine-4-carboxylate

ethyl 2-methyl-6-oxo-1H-pyrimidine-4-carboxylate

Conditions
ConditionsYield
In ethanol for 16h; Heating;10%
9-formyl-8-hydroxyjulolidine
63149-33-7

9-formyl-8-hydroxyjulolidine

diethyl oxaloacetate
108-56-5

diethyl oxaloacetate

Oxo-(10-oxo-2,3,5,6-tetrahydro-1H,4H,10H-11-oxa-3a-aza-benzo[de]anthracen-9-yl)-acetic acid ethyl ester
118043-79-1

Oxo-(10-oxo-2,3,5,6-tetrahydro-1H,4H,10H-11-oxa-3a-aza-benzo[de]anthracen-9-yl)-acetic acid ethyl ester

Conditions
ConditionsYield
With piperidine In acetonitrile for 120h; Heating;12%
L-threonine methyl ester
3373-59-9

L-threonine methyl ester

diethyl oxaloacetate
108-56-5

diethyl oxaloacetate

diethyl 2-N-(2-hydroxy-1-methoxycarbonylpropylamino)but-2-enedioate
139370-60-8

diethyl 2-N-(2-hydroxy-1-methoxycarbonylpropylamino)but-2-enedioate

Conditions
ConditionsYield
With sodium sulfate In dichloromethane for 65h; Ambient temperature;13%
5-amino-1,2,3,6-tetramethylindole

5-amino-1,2,3,6-tetramethylindole

diethyl oxaloacetate
108-56-5

diethyl oxaloacetate

diethyl (5-amino-1,2,3,6-tetramethyl-1H-indolyl)fumarate

diethyl (5-amino-1,2,3,6-tetramethyl-1H-indolyl)fumarate

Conditions
ConditionsYield
With acetic acid In benzene for 64h; Heating;16%
5,5-dimethyl-6-hydrazino-4,5-dihydro-2H-pyridazin-3-one
100568-22-7

5,5-dimethyl-6-hydrazino-4,5-dihydro-2H-pyridazin-3-one

diethyl oxaloacetate
108-56-5

diethyl oxaloacetate

diethyl 2-[(1,4,5,6-tetrahydro-4,4-dimethyl-6-oxo-3-pyridazinyl)hydrazono]butanedioate

diethyl 2-[(1,4,5,6-tetrahydro-4,4-dimethyl-6-oxo-3-pyridazinyl)hydrazono]butanedioate

Conditions
ConditionsYield
In ethanol at 20℃; for 120h;17%
[2,4,5,6-2H4]3-chloroaniline
1027104-24-0

[2,4,5,6-2H4]3-chloroaniline

diethyl oxaloacetate
108-56-5

diethyl oxaloacetate

1,4-diethyl (2E)-2-[[3-chloro(2H4)phenyl]imino]butanedioate

1,4-diethyl (2E)-2-[[3-chloro(2H4)phenyl]imino]butanedioate

Conditions
ConditionsYield
In acetic acid at 45℃;17%
5-amino-2-methylindole
7570-49-2

5-amino-2-methylindole

diethyl oxaloacetate
108-56-5

diethyl oxaloacetate

diethyl (5-amino-2-methyl-1H-indolyl)fumarate

diethyl (5-amino-2-methyl-1H-indolyl)fumarate

Conditions
ConditionsYield
With acetic acid In benzene for 50h; Heating;19%
chloroacetone
78-95-5

chloroacetone

diethyl oxaloacetate
108-56-5

diethyl oxaloacetate

ethyl 3-hydroxy-6-methyl-2-oxo-1,2-dihydropyridine-4-carboxylate
267876-32-4

ethyl 3-hydroxy-6-methyl-2-oxo-1,2-dihydropyridine-4-carboxylate

Conditions
ConditionsYield
Stage #1: chloroacetone; diethyl oxaloacetate With ammonia In tetrahydrofuran for 0.666667h;
Stage #2: With aluminum (III) chloride In tetrahydrofuran at 23℃; for 96h;
19%
Dimethylaminoguanidin*HBr
13750-16-8

Dimethylaminoguanidin*HBr

diethyl oxaloacetate
108-56-5

diethyl oxaloacetate

3-Dimethylamino-5-oxo-dihydro-1,2,4-triazin-6-yl-essigsaeureethylester
112080-99-6

3-Dimethylamino-5-oxo-dihydro-1,2,4-triazin-6-yl-essigsaeureethylester

Conditions
ConditionsYield
With sodium acetate In ethanol for 12h; Heating;20%
5-amino-1,6-dimethyl-2-phenylindole

5-amino-1,6-dimethyl-2-phenylindole

diethyl oxaloacetate
108-56-5

diethyl oxaloacetate

diethyl (5-amino-1,6-dimethyl-2-phenyl-1H-indolyl)fumarate

diethyl (5-amino-1,6-dimethyl-2-phenyl-1H-indolyl)fumarate

Conditions
ConditionsYield
With acetic acid In benzene for 40h; Heating;20%
diethyl oxaloacetate
108-56-5

diethyl oxaloacetate

5-amino-1-methyl-2-phenylindole
748799-33-9

5-amino-1-methyl-2-phenylindole

diethyl (5-amino-1-methyl-2-phenyl-1H-indolyl)fumarate

diethyl (5-amino-1-methyl-2-phenyl-1H-indolyl)fumarate

Conditions
ConditionsYield
With acetic acid In benzene for 61h; Heating;21%
6-Chloro-pyridin-3-ylamine
5350-93-6

6-Chloro-pyridin-3-ylamine

diethyl oxaloacetate
108-56-5

diethyl oxaloacetate

(6-chloro-pyridin-3-ylamino)-butenedioic acid diethyl ester
53241-89-7

(6-chloro-pyridin-3-ylamino)-butenedioic acid diethyl ester

Conditions
ConditionsYield
at 90℃; for 7h;21%
pyridine-2-carbaldehyde
1121-60-4

pyridine-2-carbaldehyde

diethyl oxaloacetate
108-56-5

diethyl oxaloacetate

diethyl 2,5-di(pyridin-2-yl)-1H-pyrrole-3,4-dicarboxylate
109694-41-9

diethyl 2,5-di(pyridin-2-yl)-1H-pyrrole-3,4-dicarboxylate

Conditions
ConditionsYield
With ammonium acetate In ethanol Reflux;22%
6-methyl-2-phenyl-1H-indol-5-ylamine

6-methyl-2-phenyl-1H-indol-5-ylamine

diethyl oxaloacetate
108-56-5

diethyl oxaloacetate

2-(6-methyl-2-phenyl-1H-indol-5-ylamino)-but-2-enedioic acid diethyl ester

2-(6-methyl-2-phenyl-1H-indol-5-ylamino)-but-2-enedioic acid diethyl ester

Conditions
ConditionsYield
With acetic acid In benzene for 33h; Heating;23%
4-Hydroxy-2-quinolone
70254-43-2, 70254-44-3

4-Hydroxy-2-quinolone

diethyl oxaloacetate
108-56-5

diethyl oxaloacetate

2,5-Dioxo-5,6-dihydro-2H-pyrano<3,2-c>quinolinyl-4-carboxylic acid ethyl ester
94192-47-9

2,5-Dioxo-5,6-dihydro-2H-pyrano<3,2-c>quinolinyl-4-carboxylic acid ethyl ester

Conditions
ConditionsYield
With ammonium acetate In nitrobenzene at 220℃; for 0.5h;25%
3-chloro(2,4,6-2H3)aniline

3-chloro(2,4,6-2H3)aniline

diethyl oxaloacetate
108-56-5

diethyl oxaloacetate

1,4-diethyl (2E)-2-[[3-chloro(2,4,6-2H3)phenyl]imino]butanedioate

1,4-diethyl (2E)-2-[[3-chloro(2,4,6-2H3)phenyl]imino]butanedioate

Conditions
ConditionsYield
In toluene at 45℃; for 6h;26%
p-toluidine
106-49-0

p-toluidine

cyclohexanecarbaldehyde
2043-61-0

cyclohexanecarbaldehyde

diethyl oxaloacetate
108-56-5

diethyl oxaloacetate

ethyl 2-cyclohexyl-4-hydroxy-5-oxo-1-(4-methylphenyl)-2,5-dihydro-1H-pyrrole-3-carboxylate
512178-20-0

ethyl 2-cyclohexyl-4-hydroxy-5-oxo-1-(4-methylphenyl)-2,5-dihydro-1H-pyrrole-3-carboxylate

Conditions
ConditionsYield
In tetrahydrofuran at 20℃;26%
2,3-dimethyl-5-amino-6-methoxyindole
135855-58-2

2,3-dimethyl-5-amino-6-methoxyindole

diethyl oxaloacetate
108-56-5

diethyl oxaloacetate

diethyl (5-amino-6-methoxy-2,3-dimethyl-1H-indolyl)fumarate

diethyl (5-amino-6-methoxy-2,3-dimethyl-1H-indolyl)fumarate

Conditions
ConditionsYield
With acetic acid In benzene for 29h; Heating;27%
2,3-dimethyl-4-aminoindole
135855-64-0

2,3-dimethyl-4-aminoindole

diethyl oxaloacetate
108-56-5

diethyl oxaloacetate

[(2,3-dimethyl-1H-indol-4-yl)amino]fumaric acid diethyl ester

[(2,3-dimethyl-1H-indol-4-yl)amino]fumaric acid diethyl ester

Conditions
ConditionsYield
With acetic acid In benzene for 44h; Heating;27%
4-nitrobenzaldehdye
555-16-8

4-nitrobenzaldehdye

aniline
62-53-3

aniline

diethyl oxaloacetate
108-56-5

diethyl oxaloacetate

ethyl 4‑hydroxy‑2‑(4‑nitrophenyl)‑5‑oxo‑1‑phenyl‑2,5‑dihydro‑1H‑pyrrole‑3‑carboxylate
131189-27-0

ethyl 4‑hydroxy‑2‑(4‑nitrophenyl)‑5‑oxo‑1‑phenyl‑2,5‑dihydro‑1H‑pyrrole‑3‑carboxylate

Conditions
ConditionsYield
In methanol; ethanol for 24h; Ambient temperature;28%
benzaldehyde
100-52-7

benzaldehyde

p-toluidine
106-49-0

p-toluidine

diethyl oxaloacetate
108-56-5

diethyl oxaloacetate

ethyl 4-hydroxy-5-oxo-2-phenyl-1-(p-tolyl)-2,5-dihydro-1H-pyrrole-3-carboxylate
147298-51-9

ethyl 4-hydroxy-5-oxo-2-phenyl-1-(p-tolyl)-2,5-dihydro-1H-pyrrole-3-carboxylate

Conditions
ConditionsYield
In ethanol at 20℃; for 24h;28%
benzaldehyde
100-52-7

benzaldehyde

4-nitro-aniline
100-01-6

4-nitro-aniline

diethyl oxaloacetate
108-56-5

diethyl oxaloacetate

ethyl 4-hydroxy-1-(4-nitrophenyl)-5-oxo-2-phenyl-2,5-dihydro-1H-pyrrole-3-carboxylate
131189-28-1

ethyl 4-hydroxy-1-(4-nitrophenyl)-5-oxo-2-phenyl-2,5-dihydro-1H-pyrrole-3-carboxylate

Conditions
ConditionsYield
In methanol; ethanol for 240h; Ambient temperature;30%
benzaldehyde
100-52-7

benzaldehyde

4-bromo-aniline
106-40-1

4-bromo-aniline

diethyl oxaloacetate
108-56-5

diethyl oxaloacetate

ethyl 1-(4-bromophenyl)-2,5-dihydro-4-hydroxy-5-oxo-2-phenyl-1H-pyrrole-3-carboxylate
139325-41-0

ethyl 1-(4-bromophenyl)-2,5-dihydro-4-hydroxy-5-oxo-2-phenyl-1H-pyrrole-3-carboxylate

Conditions
ConditionsYield
In ethanol at 20℃; for 24h;30%
4-chlorobenzylidenemalonodinitrile
1867-38-5

4-chlorobenzylidenemalonodinitrile

diethyl oxaloacetate
108-56-5

diethyl oxaloacetate

6-Amino-4-(4-chloro-phenyl)-5-cyano-4H-pyran-2,3-dicarboxylic acid diethyl ester
77151-43-0

6-Amino-4-(4-chloro-phenyl)-5-cyano-4H-pyran-2,3-dicarboxylic acid diethyl ester

Conditions
ConditionsYield
With morpholine In ethanol for 0.5h; Ambient temperature;30%
4-methoxy-benzaldehyde
123-11-5

4-methoxy-benzaldehyde

aniline
62-53-3

aniline

diethyl oxaloacetate
108-56-5

diethyl oxaloacetate

ethyl 4‑hydroxy‑2‑(4‑methoxyphenyl)‑5‑oxo‑1‑phenyl‑2,5‑dihydro‑1H‑pyrrole‑3‑carboxylate
131189-26-9

ethyl 4‑hydroxy‑2‑(4‑methoxyphenyl)‑5‑oxo‑1‑phenyl‑2,5‑dihydro‑1H‑pyrrole‑3‑carboxylate

Conditions
ConditionsYield
In methanol; ethanol for 72h; Ambient temperature;33%
2-methyl-4-nitro-3-isoxazolin-5(2H)-one
138842-45-2

2-methyl-4-nitro-3-isoxazolin-5(2H)-one

diethyl oxaloacetate
108-56-5

diethyl oxaloacetate

2,3-bis(ethoxycarbonyl)-1-methyl-4-nitropyrrole

2,3-bis(ethoxycarbonyl)-1-methyl-4-nitropyrrole

Conditions
ConditionsYield
Stage #1: diethyl oxaloacetate With sodium In ethanol
Stage #2: 2-methyl-4-nitro-3-isoxazolin-5(2H)-one In pyridine at 0 - 20℃; for 5h;
Stage #3: With ammonium chloride In ethanol at 80℃; for 10h; Further stages.;
33%
methyl-1 amino-3 pyrazole
1904-31-0

methyl-1 amino-3 pyrazole

diethyl oxaloacetate
108-56-5

diethyl oxaloacetate

A

4-ethoxycarbonyl-2-methyl-2H-pyrazolo<3,4-b>pyridin-6(7H)-one

4-ethoxycarbonyl-2-methyl-2H-pyrazolo<3,4-b>pyridin-6(7H)-one

B

3-amino-4-(1,2-bis-ethoxycarbonylvinyl)-1-methylpyrazole

3-amino-4-(1,2-bis-ethoxycarbonylvinyl)-1-methylpyrazole

C

3-(1,2-bis-ethoxycarbonylvinylamino)-1-methylpyrazole

3-(1,2-bis-ethoxycarbonylvinylamino)-1-methylpyrazole

D

ethyl α-(3-amino-1-methyl-4-pyrazolyl)-β-acrylate

ethyl α-(3-amino-1-methyl-4-pyrazolyl)-β-acrylate

Conditions
ConditionsYield
Ambient temperature;A 33.1%
B 5.9%
C 32.9%
D 20.5%
5-amino-2,3-dimethylindole
16712-58-6

5-amino-2,3-dimethylindole

diethyl oxaloacetate
108-56-5

diethyl oxaloacetate

diethyl (5-amino-2,3-dimethyl-1H-indolyl)fumarate

diethyl (5-amino-2,3-dimethyl-1H-indolyl)fumarate

Conditions
ConditionsYield
With acetic acid In benzene for 30h; Heating;34%
N,N,N-(ferrocenylmethyl)trimethylammonium iodide

N,N,N-(ferrocenylmethyl)trimethylammonium iodide

diethyl oxaloacetate
108-56-5

diethyl oxaloacetate

(C10H9FeCH2)2C(COOC2H5)COCOOC2H5

(C10H9FeCH2)2C(COOC2H5)COCOOC2H5

Conditions
ConditionsYield
In N,N-dimethyl-formamide boiling;35%
In N,N-dimethyl-formamide boiling;35%

108-56-5Relevant articles and documents

Bigg

, p. 571,573,574 (1976)

Impact of Stereo- And Regiochemistry on Energetic Materials

Barton, Lisa M.,Edwards, Jacob T.,Johnson, Eric C.,Bukowski, Eric J.,Sausa, Rosario C.,Byrd, Edward F. C.,Orlicki, Joshua A.,Sabatini, Jesse J.,Baran, Phil S.

supporting information, p. 12531 - 12535 (2019/08/26)

The synthesis, physical properties, and calculated performances of six stereo- and regioisomeric cyclobutane nitric ester materials are described. While the calculated performances of these isomers, as expected, were similar, their physical properties were found to be extremely different. By alteration of the stereo- and regiochemistry, complete tunability in the form of low- or high-melting solids, stand-alone melt-castable explosives, melt-castable explosive eutectic compounds, and liquid propellant materials was obtained. This demonstrates that theoretical calculations should not be the main factor in driving the design of new materials and that stereo- and regiochemistry matter in the design of compounds of potential relevance to energetic formulators.

Pyrrolone Derivatives as Intracellular Allosteric Modulators for Chemokine Receptors: Selective and Dual-Targeting Inhibitors of CC Chemokine Receptors 1 and 2

Ortiz Zacarías, Natalia V.,Van Veldhoven, Jacobus P. D.,Portner, Laura,Van Spronsen, Eric,Ullo, Salviana,Veenhuizen, Margo,Van Der Velden, Wijnand J. C.,Zweemer, Annelien J. M.,Kreekel, Roy M.,Oenema, Kenny,Lenselink, Eelke B.,Heitman, Laura H.,Ijzerman, Adriaan P.

, p. 9146 - 9161 (2018/10/24)

The recent crystal structures of CC chemokine receptors 2 and 9 (CCR2 and CCR9) have provided structural evidence for an allosteric, intracellular binding site. The high conservation of residues involved in this site suggests its presence in most chemokine receptors, including the close homologue CCR1. By using [3H]CCR2-RA-[R], a high-affinity, CCR2 intracellular ligand, we report an intracellular binding site in CCR1, where this radioligand also binds with high affinity. In addition, we report the synthesis and biological characterization of a series of pyrrolone derivatives for CCR1 and CCR2, which allowed us to identify several high-affinity intracellular ligands, including selective and potential multitarget antagonists. Evaluation of selected compounds in a functional [35S]GTPγS assay revealed that they act as inverse agonists in CCR1, providing a new manner of pharmacological modulation. Thus, this intracellular binding site enables the design of selective and multitarget inhibitors as a novel therapeutic approach.

Preparation method of 2-nitropyrimidine derivative

-

Paragraph 0021; 0022, (2017/08/29)

The invention discloses a preparation method of 2-nitropyrimidine derivative which is methyl 6-chloro-2-nitropyrimidine-4-carboxylate. The method comprises the following steps: taking diethyl oxalate as a starting raw material, and carrying out condensation, cyclization, chlorination and esterification to obtain a target product. The compound is used as an important medical intermediate.

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 108-56-5