5443-21-0 Usage
Uses
Used in Material Science:
1,5-BIS(MALEIMIDE)PENTANE is used as a reactive compound for the synthesis of polymers, adhesives, and coatings. Its high reactivity towards thiol groups enables the formation of stable thioether linkages, contributing to the development of high-performance materials.
Used in Organic Chemistry:
1,5-BIS(MALEIMIDE)PENTANE is used as a versatile building block in organic chemistry for the creation of various chemical structures and compounds. Its ability to react with thiol-containing molecules allows for the formation of thioether linkages, which can be utilized in the synthesis of complex organic molecules.
Used in Bioconjugation:
1,5-BIS(MALEIMIDE)PENTANE is used as a crosslinking agent in bioconjugation processes. Its reactivity with thiol groups allows for the formation of stable thioether linkages between biomolecules, enabling the development of novel bioconjugates for research and therapeutic applications.
Used in Drug Delivery Systems:
1,5-BIS(MALEIMIDE)PENTANE is used as a component in the design and fabrication of drug delivery systems. Its ability to form stable thioether linkages with thiol-containing molecules can be employed to create targeted drug delivery systems, improving the efficacy and bioavailability of therapeutic agents.
Used in Chemical Research:
1,5-BIS(MALEIMIDE)PENTANE is used as a research tool in chemical research to explore new reactions, develop novel synthetic strategies, and investigate the properties of thioether linkages in various chemical systems. Its versatility and reactivity make it an important compound in advancing the field of chemistry.
Check Digit Verification of cas no
The CAS Registry Mumber 5443-21-0 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 5,4,4 and 3 respectively; the second part has 2 digits, 2 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 5443-21:
(6*5)+(5*4)+(4*4)+(3*3)+(2*2)+(1*1)=80
80 % 10 = 0
So 5443-21-0 is a valid CAS Registry Number.
5443-21-0Relevant academic research and scientific papers
An efficient reverse Diels-Alder approach for the synthesis of N-alkyl bismaleimides
Rao, Venkataramanarao,Navath, Suryakiran,Kottur, Mohankumar,McElhanon, James R.,McGrath, Dominic V.
, p. 5011 - 5013 (2013/09/02)
Bismaleimides are useful precursors for Diels-Alder reactions, Michael additions, and thiol-maleimide based conjugation for the synthesis of materials and polymers. Use of bismaleimide cross linkers for generating polymers, bioconjugate molecules, and useful imaging molecules is an active area of research. An efficient and practical synthetic protocol for N-alkyl bis-maleimide cross linkers starting from furan protected maleimide employing a reverse Diels-Alder reaction is reported.
A two-directional strategy for the diversity-oriented synthesis of macrocyclic scaffolds
O'Connell, Kieron M. G.,Beckmann, Henning S. G.,Laraia, Luca,Horsley, Helen T.,Bender, Andreas,Venkitaraman, Ashok R.,Spring, David R.
supporting information, p. 7545 - 7551 (2012/10/29)
Macrocyclic compounds represent a structural class with exceptional potential for biological activity; however, they have historically been underrepresented in screening collections and synthetic libraries. In this article we report the development of a highly step-efficient strategy for the diversity-oriented synthesis of complex macrocyclic architectures, using a modular approach based on the two-directional synthesis of bifunctional linear precursors and their subsequent combination in a two-directional macrocyclisation process. In this proof of principle study, the synthesis of 14 such compounds was achieved. Cheminformatic analysis of the compounds produced suggests that they reside in biologically relevant regions of chemical space and the compounds were screened for activity against two cancer cell lines.
