5443-62-9Relevant academic research and scientific papers
Synthesis of Enaminones by a Palladium-Catalyzed Four-Component Carbonylative Addition Reaction
Wang, Liangguang,Ma, Juan,Chen, Xia,Zhou, Xiaoyu
, p. 2680 - 2684 (2017)
A palladium-catalyzed carbonylative addition reaction of aryl bromides, amines, and alkynes has been developed. The reaction occurs readily in N, N -dimethylformamide with PdCl 2 (PPh 3) 2 as a catalyst to give the corresponding enaminones in medium to excellent yields. Furthermore, a mechanism for the palladium-catalyzed four-component carbonylative addition reaction is proposed.
The synthesis of β-enaminones using trialkylamines and a Pd/DNA catalyst
Mart,Trzeciak
, (2021/02/03)
A new one-pot procedure leading to β-enaminones has been developed. The elaborated methodology involves the cascade sequencing of carbonylative Sonogashira coupling of aryl iodide with a terminal alkyne and the oxidative dealkylation of tertiary amines. The efficient syntheses of β-enaminones were performed with a Pd/DNA catalyst, with NEt3, NPr3 and NBu3 used as amine sources. The catalyst was successfully recovered and used in several subsequent tests with the same results. The reaction mechanism, summarizing the activity of immobilized Pd NPs (palladium nanoparticles), was proposed.
