54436-55-4

Basic information

• Product Name: C₁₂H₁₆ClN
• Synonyms: C₁₂H₁₆ClN
• CAS NO: 54436-55-4
• Molecular Weight: 209.719
• Mol File: 54436-55-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: C₁₂H₁₆ClN(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₂H₁₆ClN(54436-55-4)
• EPA Substance Registry System: C₁₂H₁₆ClN(54436-55-4)

Safety Data

• Hazardous Substances Data: 54436-55-4(Hazardous Substances Data)

Upstream product

• 54436-58-7 N-benzylpent-4-en-1-amine 

Downstream Products

• 1428989-18-7 1-benzyl-2-(fluoromethyl)pyrrolidine 
• 54436-59-8 1-benzyl-3-chloropiperidine 
• 60169-68-8 2-azidomethyl-1-benzylpyrrolidine 
• 60169-69-9 3-azido-1-benzylpiperidine 
• 1043963-16-1 N-benzyl-4-methyl-N-(pent-4-en-1-yl)benzenesulfonamide 

Relevant articles and documents

One-pot synthesis of 3-azido- and 3-aminopiperidines by intramolecular cyclization of unsaturated amines

A highly efficient one-pot synthesis of 3- azidopiperidines has been achieved by an intramolecular cyclization of unsaturated amines that allows for the nucleophilic installation of an azide moiety. This method unlocks the versatile employment of the azide functionality in the preparation and biological studies of piperidine-containing structures. This strategy has been expanded for the direct incorporation of a variety of nitrogen nucleophiles, and thus it provides a rapid and modular synthesis of 3-amino and 3- amidopiperidines of important pharmaceutical and biological relevance. Particularly noteworthy is that the regioselectivity of this transformation enables the formation of the anti- Markovnikov-type adduct, complementing Markovnikov-based olefin amino functionalization methods.