60169-68-8Relevant academic research and scientific papers
One-pot synthesis of 3-azido- and 3-aminopiperidines by intramolecular cyclization of unsaturated amines
Ortiz, Gerardo X.,Kang Jr., Bora,Wang, Qiu
, p. 571 - 581 (2014/04/03)
A highly efficient one-pot synthesis of 3- azidopiperidines has been achieved by an intramolecular cyclization of unsaturated amines that allows for the nucleophilic installation of an azide moiety. This method unlocks the versatile employment of the azide functionality in the preparation and biological studies of piperidine-containing structures. This strategy has been expanded for the direct incorporation of a variety of nitrogen nucleophiles, and thus it provides a rapid and modular synthesis of 3-amino and 3- amidopiperidines of important pharmaceutical and biological relevance. Particularly noteworthy is that the regioselectivity of this transformation enables the formation of the anti- Markovnikov-type adduct, complementing Markovnikov-based olefin amino functionalization methods.
PYRIDINE-3-CARBOXYAMIDE DERIVATIVE
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Page/Page column 112, (2011/10/12)
To provide a novel JAK3 inhibitor that is useful as a preventive and/or therapeutic agent for rejection and graft versus host disease (GvHD) in organ transplantation, rheumatoid arthritis, multiple sclerosis, systemic lupus erythematosus, Sj?gren syndrome, Behcet's disease, type I diabetes mellitus, autoimmune thyroiditis, idiopathic thrombocytopenic purpura, ulcerative colitis, Crohn's disease, asthma, allergic rhinitis, atopic dermatitis, contact dermatitis, urticaria, eczema, psoriasis, allergic conjunctivitis, uveitis, cancer, leukemia and the like. The pyridine-3-carboxyamide derivative represented by the general formula (1): or its salt or a solvate thereof.
