544463-71-0

Basic information

• Product Name: 4-((4-(2,4-dichlorophenyl)thiazol-2-yl)amino)-4-oxobutanoic acid
• Synonyms: 4-((4-(2,4-dichlorophenyl)thiazol-2-yl)amino)-4-oxobutanoic acid
• CAS NO: 544463-71-0
• Molecular Weight: 345.206
• Mol File: 544463-71-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-((4-(2,4-dichlorophenyl)thiazol-2-yl)amino)-4-oxobutanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-((4-(2,4-dichlorophenyl)thiazol-2-yl)amino)-4-oxobutanoic acid(544463-71-0)
• EPA Substance Registry System: 4-((4-(2,4-dichlorophenyl)thiazol-2-yl)amino)-4-oxobutanoic acid(544463-71-0)

Safety Data

• Hazardous Substances Data: 544463-71-0(Hazardous Substances Data)

Upstream product

• 1398574-79-2 C₁₄H₁₂Cl₂N₂O₃S 
• 93209-97-3 4-(2,4-dichlorophenyl)-1,3-thiazol-2-amine 
• 2631-72-3 2,4-dichlorophenacyl bromide 

Relevant articles and documents

Design, synthesis and biological evaluation of thiazole- and indole-based derivatives for the treatment of type II diabetes

Present studies have shown that the lipid carrier has a significant role in several aspects of metabolic syndrome in A-FABP/ap2-deficient mice, including type 2 diabetes and atherosclerosis. 38 Thiazole- and indole-based derivatives were synthesized and investigated for their inhibitory effects on the production of LPS-stimulated TNF-α. Among them, 12b exhibited an excellent inhibitory efficiency compared to BMS309403 (95% vs. 85%) at the concentration of 10 μM and a binding affinity for ap2 with the apparent Ki values 33 nM. Oral administration of 12b at a dosage of 50 mg/kg effectively reduced the levels of plasma blood glucose, triglycerides, insulin, total cholesterol and alanine aminotransferase in high-fat/diet-induced obesity model. The results highlighted that 12b was a potent anti-diabetic agent.