544466-52-6

Basic information

• Product Name: ethyl [5-(diphenylphosphino)-2-(morpholin-4-yl-1,3-thiazol-4-yl)]acetate
• Synonyms: ethyl [5-(diphenylphosphino)-2-(morpholin-4-yl-1,3-thiazol-4-yl)]acetate
• CAS NO: 544466-52-6
• Molecular Weight: 440.503
• Mol File: 544466-52-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: ethyl [5-(diphenylphosphino)-2-(morpholin-4-yl-1,3-thiazol-4-yl)]acetate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl [5-(diphenylphosphino)-2-(morpholin-4-yl-1,3-thiazol-4-yl)]acetate(544466-52-6)
• EPA Substance Registry System: ethyl [5-(diphenylphosphino)-2-(morpholin-4-yl-1,3-thiazol-4-yl)]acetate(544466-52-6)

Safety Data

• Hazardous Substances Data: 544466-52-6(Hazardous Substances Data)

Upstream product

• 1079-65-8 Bromodiphenylphosphin 
• 329906-01-6 ethyl (2-morpholin-4-yl-1,3-thiazol-4-yl)acetate 

Downstream Products

• 544466-66-2 [5-(diphenylphosphino)-2-(morpholin-4-yl)-1,3-thiazol-4-yl]acetic acid 

Relevant articles and documents

Palladium-catalyzed Suzuki cross-coupling of aryl halides with aryl boronic acids in the presence of glucosamine-based phosphines

Carbohydrate-substituted phosphines are easily obtained in quite good yields by coupling of protected or non-protected d-glucosamine with the corresponding diphenylphosphino acid. These neutral ligands, in association with palladium acetate, are very active catalysts in the Suzuki cross-coupling reaction. The polyhydroxy phosphines are more active than the peracetylated phosphines. The process tolerates electron-rich as well as electron-poor substituents. Excellent turnovers, up to 97 000 are observed.