544466-66-2

Basic information

• Product Name: [5-(diphenylphosphino)-2-(morpholin-4-yl)-1,3-thiazol-4-yl]acetic acid
• Synonyms: [5-(diphenylphosphino)-2-(morpholin-4-yl)-1,3-thiazol-4-yl]acetic acid
• CAS NO: 544466-66-2
• Molecular Weight: 412.449
• Mol File: 544466-66-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: [5-(diphenylphosphino)-2-(morpholin-4-yl)-1,3-thiazol-4-yl]acetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: [5-(diphenylphosphino)-2-(morpholin-4-yl)-1,3-thiazol-4-yl]acetic acid(544466-66-2)
• EPA Substance Registry System: [5-(diphenylphosphino)-2-(morpholin-4-yl)-1,3-thiazol-4-yl]acetic acid(544466-66-2)

Safety Data

• Hazardous Substances Data: 544466-66-2(Hazardous Substances Data)

Upstream product

• 329906-01-6 ethyl (2-morpholin-4-yl-1,3-thiazol-4-yl)acetate 
• 1079-65-8 Bromodiphenylphosphin 
• 544466-52-6 ethyl [5-(diphenylphosphino)-2-(morpholin-4-yl-1,3-thiazol-4-yl)]acetate 

Relevant articles and documents

Palladium-catalyzed Suzuki cross-coupling of aryl halides with aryl boronic acids in the presence of glucosamine-based phosphines

Carbohydrate-substituted phosphines are easily obtained in quite good yields by coupling of protected or non-protected d-glucosamine with the corresponding diphenylphosphino acid. These neutral ligands, in association with palladium acetate, are very active catalysts in the Suzuki cross-coupling reaction. The polyhydroxy phosphines are more active than the peracetylated phosphines. The process tolerates electron-rich as well as electron-poor substituents. Excellent turnovers, up to 97 000 are observed.