5446-05-9

Basic information

• Product Name: 1-IODO-2-NITRO-4-CHLOROBENZENE
• Synonyms: 5-Chloro-2-iodonitrobenzene;4-Chloro-2-nitrophenyl iodide;NSC 17163;4-choro-1-iode-2-nitrobenzene;1-IODO-2-NITRO-4-CHLOROBENZENE
• CAS NO: 5446-05-9
• Molecular Formula: C₆H₃ClINO₂
• Molecular Weight: 283.45
• Mol File: 5446-05-9.mol
• Article Data: 4

Chemical Properties

• Melting Point: 59℃
• Boiling Point: 297.7°C at 760 mmHg
• Flash Point: 133.9°C
• Appearance: /
• Density: 2.094g/cm³
• Vapor Pressure: 0.00235mmHg at 25°C
• Refractive Index: 1.671
• Storage Temp.: 2-8°C(protect from light)
• CAS DataBase Reference: 1-IODO-2-NITRO-4-CHLOROBENZENE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-IODO-2-NITRO-4-CHLOROBENZENE(5446-05-9)
• EPA Substance Registry System: 1-IODO-2-NITRO-4-CHLOROBENZENE(5446-05-9)

Safety Data

• Hazardous Substances Data: 5446-05-9(Hazardous Substances Data)

Usage

General Description

1-Iodo-2-nitro-4-chlorobenzene is a chemical compound that belongs to the class of halogenated aromatic compounds. It consists of a benzene ring with a chlorine atom at the 4-position, an iodo group at the 1-position, and a nitro group at the 2-position. 1-IODO-2-NITRO-4-CHLOROBENZENE is commonly used in organic synthesis and pharmaceutical industries for the production of various chemical intermediates. It is also utilized in research and development as a building block for the synthesis of other organic compounds. 1-Iodo-2-nitro-4-chlorobenzene is considered to be a hazardous chemical and proper safety measures should be taken when handling and storing it.

InChI:InChI=1/C6H3ClINO2/c7-4-1-2-5(8)6(3-4)9(10)11/h1-3H

Upstream product

• 106-46-7 para-dichlorobenzene 
• 787633-79-8 (R,S)-1-(4-chloro-2-nitrophenyl)ethanol 
• 6280-88-2 4-chloro-2-nitro-benzoic acid 
• 71-43-2 benzene 

Downstream Products

• 136808-72-5 2-iodo-5-chlorophenol 
• 1079437-49-2 C₁₆H₁₀ClN₃O₂S 
• 1189051-94-2 4-chloro-2-nitro-1-[2-(trimethylsilyl)ethynyl]benzene 
• 1219744-23-6 1-allyl-4-chloro-2-nitrobenzene 
• 153042-35-4 (S)-4-[2-(2-Amino-4-chloro-phenyl)-2-oxo-ethyl]-5-oxo-oxazolidine-3-carboxylic acid benzyl ester 
• 175777-22-7 L-4-chlorokynurenine 
• 153042-33-2 tert-butyl (5-chloro-2-iodophenyl)carbamate 
• 274926-27-1 (E)-2-[(5-chloro-2-iodo-phenyl)-(4-methoxybenzyl)-carbamoyl]-5-phenylcarbamoyl-pent-4-enoic acid tert-butyl ester 

Relevant articles and documents

Dehydroxyalkylative halogenation of C(aryl)-C bonds of aryl alcohols

We herein report Cu mediated side-directed dehydroxyalkylative halogenation of aryl alcohols. C(aryl)-C bonds of aryl alcohols were effectively cleaved, affording the corresponding aryl chlorides, bromides and iodides in excellent yields. Aryl alcohols could serve as both aromatic electrophilic and radical synthetic equivalents during the reaction.

Synthetic method of aryl halide taking aryl carboxylic acid as raw material

A synthetic method of an aryl halide taking aryl carboxylic acid as a raw material is characterized in that a corresponding aryl halide is formed by carrying out substitution reaction on an aryl carboxylic acid compound and haloid salt MX in an organic solvent under the condition that oxygen, a silver catalyst, a copper additive and a bidentate nitrogen ligand exist, wherein M in MX represents alkali metal or alkaline earth metal, and X represents F, Cl, Br or I. Compared with a conventional aryl halide synthetic method, the synthetic method disclosed by the invention has the obvious advantages that reaction raw materials (comprising aryl carboxylic acid and MX) are cheap and easy to obtain, the using amount of a metal catalyst is small, pollution to the environment when the oxygen is used as an oxidant is the smallest, good tolerance to various functional groups on an aromatic ring is obtained, the yield is high, and the like. The synthetic method disclosed by the invention can be widely applied to synthesis in the fields of medicine, materials, natural products and the like in industry and academia.