787633-79-8

Basic information

• Product Name: (R,S)-1-(4-chloro-2-nitrophenyl)ethanol
• Synonyms: (R,S)-1-(4-chloro-2-nitrophenyl)ethanol
• CAS NO: 787633-79-8
• Molecular Weight: 201.609
• Mol File: 787633-79-8.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: (R,S)-1-(4-chloro-2-nitrophenyl)ethanol(CAS DataBase Reference)
• NIST Chemistry Reference: (R,S)-1-(4-chloro-2-nitrophenyl)ethanol(787633-79-8)
• EPA Substance Registry System: (R,S)-1-(4-chloro-2-nitrophenyl)ethanol(787633-79-8)

Safety Data

• Hazardous Substances Data: 787633-79-8(Hazardous Substances Data)

Upstream product

• 5551-11-1 4-Chloro-2-nitrobenzaldehyde 
• 917-54-4 methyllithium 
• 23082-51-1 4'-chloro-2'-nitroacetophenone 

Downstream Products

• 89-61-2 2,5-dichloronitrobenzene 
• 41513-04-6 2-chloro-5-bromonitrobenzene 
• 5446-05-9 4-chloro-2-nitroiodobenzene 
• 4548-56-5 4-chloro-2-nitrophenyl phenyl sulfide 
• 121-73-3 3-Nitrochlorobenzene 
• 787633-82-3 (R,S)-1-(4-chloro-2-nitrophenyl)ethylamine 
• 907198-92-9 4-[1-(4-chloro-2-nitro-phenyl)-ethyl]-3-(4-chloro-phenyl)-7-iodo-1-[3-(4-methyl-piperazin-1-yl)-propyl]-3,4-dihydro-1H-benzo[e][1,4]diazepine-2,5-dione 
• 907198-49-6 4-[1-(4-chloro-2-nitro-phenyl)-ethyl]-3-(4-chloro-phenyl)-7-iodo-1-(2-morpholin-4-yl-ethyl)-3,4-dihydro-1H-benzo[e][1,4]diazepine-2,5-dione 

Relevant articles and documents

Dehydroxyalkylative halogenation of C(aryl)-C bonds of aryl alcohols

We herein report Cu mediated side-directed dehydroxyalkylative halogenation of aryl alcohols. C(aryl)-C bonds of aryl alcohols were effectively cleaved, affording the corresponding aryl chlorides, bromides and iodides in excellent yields. Aryl alcohols could serve as both aromatic electrophilic and radical synthetic equivalents during the reaction.

Enantiomerically pure 1,4-benzodiazepine-2,5-diones as Hdm2 antagonists

The 1,4-benzodiazepine-2,5-dione is a suitable template to disrupt the interaction between p53 and Hdm2. The development of an enantioselective synthesis disclosed the stereochemistry of the active enantiomer. An in vitro p53 peptide displacement assay identified active compounds. These activities were confirmed in several cell-based assays including induction of the p53 regulated gene (PIG-3) and caspase activity.

Novel 1,4-benzodiazepine-2,5-diones as Hdm2 antagonists with improved cellular activity

The disruption of the p53-Hdm2 protein-protein interaction induces cell growth arrest and apoptosis. We have identified the 1,4-benzodiazepine-2,5-dione scaffold as a suitable template for inhibiting this interaction by binding to the Hdm2 protein. Several compounds have been made with improved potency, solubility, and cell-based activities.