5446-25-3

Basic information

• Product Name: 3-chloro-N-(3,4-dimethylphenyl)propanamide
• Synonyms: UKRORGSYN-BB BBV-024046;3-chloro-N-(3,4-dimethylphenyl)propanamide(SALTDATA: FREE);3-chloro-N-(3,4-dimethylphenyl)propionamide;3-chloro-N-(3,4-dimethylphenyl)propanamide
• CAS NO: 5446-25-3
• Molecular Formula: C₁₁H₁₄ClNO
• Molecular Weight: 211.69
• Mol File: 5446-25-3.mol

Chemical Properties

• Boiling Point: 369.4°C at 760 mmHg
• Flash Point: 177.2°C
• Appearance: /
• Density: 1.157g/cm³
• Vapor Pressure: 1.19E-05mmHg at 25°C
• Refractive Index: 1.565
• CAS DataBase Reference: 3-chloro-N-(3,4-dimethylphenyl)propanamide(CAS DataBase Reference)
• NIST Chemistry Reference: 3-chloro-N-(3,4-dimethylphenyl)propanamide(5446-25-3)
• EPA Substance Registry System: 3-chloro-N-(3,4-dimethylphenyl)propanamide(5446-25-3)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 5446-25-3(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
3-chloro-N-(3,4-dimethylphenyl)propanamide serves as a crucial intermediate in the synthesis of pharmaceuticals. Its unique structure and reactivity contribute to the development of new drugs with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical sector, 3-chloro-N-(3,4-dimethylphenyl)propanamide is utilized as an intermediate for the production of various agrochemicals, including pesticides and herbicides, due to its ability to form active ingredients with desired biological properties.
Used in Polymer and Plastics Production:
3-chloro-N-(3,4-dimethylphenyl)propanamide also finds application in the manufacturing of polymers and plastics, where it acts as a building block for creating materials with specific properties required for different industrial uses.
Used in Research Applications:
Due to its chemical properties, 3-chloro-N-(3,4-dimethylphenyl)propanamide is employed in research settings for studying reaction mechanisms, exploring new synthetic routes, and developing innovative compounds for various applications.

InChI:InChI=1/C11H14ClNO/c1-8-3-4-10(7-9(8)2)13-11(14)5-6-12/h3-4,7H,5-6H2,1-2H3,(H,13,14)

Upstream product

• 95-64-7 4-amino-o-xylene 
• 625-36-5 2-chloropropionyl chloride 

Downstream Products

• 182052-67-1 2-Chloro-3-chloromethyl-6,7-dimethyl-quinoline 
• 1012918-33-0 3-(diethylamino)-N-(3,4-dimethyl-phenyl)propionamide 
• 60284-48-2 1-(3,4-dimethyl-phenyl)-azetidin-2-one 

Relevant articles and documents

Design, synthesis and SAR exploration of tri-substituted 1,2,4-triazoles as inhibitors of the annexin A2-S100A10 protein interaction

Recent target validation studies have shown that inhibition of the protein interaction between annexin A2 and the S100A10 protein may have potential therapeutic benefits in cancer. Virtual screening identified certain 3,4,5-trisubstituted 4H-1,2,4-triazoles as moderately potent inhibitors of this interaction. A series of analogues were synthesized based on the 1,2,4-triazole scaffold and were evaluated for inhibition of the annexin A2-S100A10 protein interaction in competitive binding assays. 2-[(5-{[(4,6-Dimethylpyrimidin-2-yl)sulfanyl]methyl}-4-(furan-2-ylmethyl)-4H-1,2,4-triazol-3-yl)sulfanyl]-N-[4-(propan-2-yl)phenyl]acetamide (36) showed improved potency and was shown to disrupt the native complex between annexin A2 and S100A10.

Synthesis and antispasmodic activity of lidocaine derivatives endowed with reduced local anesthetic action

The present structure-activity relationship (SAR) study focused on chemical modifications of the structure of the local anesthetic lidocaine, and indicated analogues having reduced anesthetic potency, but with superior potency relative to the prototype in preventing anaphylactic or histamine-evoked ileum contraction. From the SAR analysis, 2-(diethylamino)-N-(trifluoromethyl-phenyl) and 2-(diethylamino)-N-(dimethyl-phenyl) acetamides were selected as the most promising compounds. New insights into the applicability of non-anesthetic lidocaine derivatives as templates in drug discovery for allergic syndromes are provided.

New heteroaryl-spaced phosphono α-amino acids are competitive NMDA antagonists with analgesic activity

The synthesis and the NMDA receptor binding affinities of α-amino-3-(phosphonomethyl)-2-naphthalenepropanoic acid, α-amino-3-(phosphonomethyl)-2-benzofuranpropanoic acid, a series of substituted (R)-α-amino-3-(phosphonomethyl)-2-quinolinepropanoic acids, (R)-α-amino-3-(phosphonomethyl)-1,8-naphthyridine-2-propanoic acid and (R)-α-amino-3-(phosphonomethyl)-1,6-naphthyridine-2-propanoic acid are reported.

Herbicidal N-aryl substituted azetidinones

Disclosed are herbicidal compositions comprising an inert carrier and as an essential active ingredient in a quantity toxic to weeds a compound of the formula EQU1 wherein X is selected from the group consisting of alkyl, alkenyl, alkoxy, alkylthio, halogen, haloalkyl and nitro; and n is an integer from 0 to 5.