5446-58-2

Usage

Uses

Used in Organic Synthesis:
N-P-Toluenesulfonylimino-3,3'-dipropionic acid is used as a reagent for the preparation of amides and esters, facilitating the synthesis of various organic compounds. Its reactivity and ability to form stable intermediates make it an essential component in the development of new chemical entities and the modification of existing ones.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, N-P-Toluenesulfonylimino-3,3'-dipropionic acid is utilized as a key intermediate in the synthesis of drug molecules. Its unique properties allow for the creation of novel compounds with potential therapeutic applications, contributing to the advancement of medicinal chemistry.
Used in Chemical Research:
N-P-Toluenesulfonylimino-3,3'-dipropionic acid is also employed in chemical research for studying reaction mechanisms and exploring new synthetic pathways. Its reactivity and stability make it a valuable tool for understanding and optimizing chemical reactions, leading to the discovery of more efficient and sustainable synthetic methods.

Upstream product

• 2619-16-1 N,N-bis[(2-cyanoethyl)]-4-methylbenzenesulfonamide 
• 3518-88-5 3,3'-imino-di-propionic acid diethyl ester 
• 98-59-9 p-toluenesulfonyl chloride 
• 111-94-4 3,3'-Iminodipropionitrile 
• 18773-54-1 4-methyl-N,N-diprop-2-ynylbenzenesulfonamide 

Downstream Products

• 56187-12-3 N-tosyl-bis(3-hydroxypropyl)amine 
• 116073-66-6 N-tosyl-3,3'-iminobis-1-(3-aminopropoxy)propane 
• 116073-65-5 N-tosyl-3,3'-iminobis-1-(2-cyanoethoxy)propane 
• 116073-68-8 5-tosyl-1,9,17-trioxa-5,13,21-triazacyclotetracosane 
• 116073-67-7 21-tosyl-1,9,17-trioxa-5,13,21-triazacyclotetracosane-6,12-dione 
• 116073-78-0 C₄₁H₅₁Cl₂N₃O₉S 
• 116073-77-9 C₄₁H₅₃N₃O₁₁S 
• 116073-83-7 C₄₂H₄₈Cl₃N₃O₉ 
• 116073-82-6 5,13,21-tris(4-carboxybenzoyl)-1,9,17-trioxa-5,13,21-triazacyclotetracosane 
• 116102-08-0 5,13-bis(4'-methoxycarbonylbenzoyl)-21-tosyl-1,9,17-trioxa-5,13,21-triazacyclotetracosane 
• 116073-81-5 C₄₅H₅₇N₃O₁₂ 
• 116073-79-1 C₆₆H₉₄N₆O₁₄S₂ 
• 112672-90-9 benzo-1,5,9-triacylododecane N,N',N''-tritosylamide 
• 35980-67-7 1,5,9-tritosyl-1,5,9-triazacyclododecane 

Relevant academic research and scientific papers

Oxidation of Alkynyl Boronates to Carboxylic Acids, Esters, and Amides

A general efficient protocol was developed for the synthesis of carboxylic acids, esters, and amides through oxidation of alkynyl boronates, generated directly from terminal alkynes. This protocol represents the first example of C(sp)?B bond oxidation. This approach displays a broad substrate scope, including aryl and alkyl alkynes, and exhibits excellent functional group tolerance. Water, primary and secondary alcohols, and amines are suitable nucleophiles for this transformation. Notably, amino acids and peptides can be used as nucleophiles, providing an efficient method for the synthesis and modification of peptides. The practicability of this methodology was further highlighted by the preparation of pharmaceutical molecules.

MACROCYCLIC AND MACROPOLYCYCLIC COMPOUNDS BASED UPON 1,3-DISUBSTITUTED PROPANE UNITS

Synthetic routes to the macrocyclic polyamine derivatives (1) and (3) are described, together with an investigation of the complexing properties of the triamines (1d) and (3d) with primary alkylammonium cations.Macrotricyclic and macrotetracyclic compounds may be obtained from the macrocycle (1) by a stepwise procedure whereas macrocycle (3b) can be converted into a macrotricyclic derivative in a one step alkylation procedure.The alkylation of the tetrahydropyrimidone (18) with α,α'-dibromo-m-xylene gives the calix arene analogue (19) which adopts the 'cone' (21a) and '1,3-alternate' (21b) conformations.The macrocyclic hexa-amine (23) may be synthesized by a simple alkylation procedure whereas the octa-amine (27) required a systematic stepwise synthesis.The hexa-amine salt (23)*6 HBr shows selectivity in forming inclusion complexes with the dicarboxylate anions (1-)O2C(CH2)nCO2(1-).

SYNTHESIS OF 2,3,5,6-TETRAHYDRO-1H,4H,11cH-3a,6a,11b-TRIAZABENZANTHRACENE (5) AND X-RAY CRYSTAL STRUCTURE DETERMINATIONS OF (5), HEXAHYDRO-1H,4H,7H,9bH-3a,6a,9a-TRIAZAPHENALENE (1), BENZO-1,5,9-TRIAZADODECANE N,N',N''-TRITOSYLAMIDE, AND OF 1,5,9-TRIAZADODECANE N,N'N''-TRITOSYLAMID

The synthesis of 2,3,5,6-tetrahydro-1H,4H,11cH-3a,6a,11b-triazabenzanthracene (5) is described.X-ray crystal structure determinations on hexahydro-1H,4H,7H,9bH-3a,6a,9a-triazaphenalene (1) and its benzoanaloque (5) show them to adopt differing conformations; the reasons for this are discussed.