35980-67-7

Basic information

• Product Name: 1,5,9-Triazacyclododecane, 1,5,9-tris[(4-methylphenyl)sulfonyl]-
• CAS NO: 35980-67-7
• Molecular Formula: C30H39N3O6S3
• Molecular Weight: 633.854
• Mol File: 35980-67-7.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 1,5,9-Triazacyclododecane, 1,5,9-tris[(4-methylphenyl)sulfonyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,5,9-Triazacyclododecane, 1,5,9-tris[(4-methylphenyl)sulfonyl]-(35980-67-7)
• EPA Substance Registry System: 1,5,9-Triazacyclododecane, 1,5,9-tris[(4-methylphenyl)sulfonyl]-(35980-67-7)

Safety Data

• Hazardous Substances Data: 35980-67-7(Hazardous Substances Data)

Upstream product

• 35980-64-4 1,5,9-Tritosyl-1,5,9-triazanonane 
• 109-64-8 1,3-dibromo-propane 
• 98-59-9 p-toluenesulfonyl chloride 
• 5469-66-9 propane-1,3-diol ditosylate 
• 56187-12-3 N-tosyl-bis(3-hydroxypropyl)amine 
• 5446-58-2 3,3'-iminodipropanoic acid tosylamide 
• 3518-88-5 3,3'-imino-di-propionic acid diethyl ester 
• 56-18-8 bis(3-aminopropyl)amine 
• 53364-99-1 N,N'-ditoluenesulfonyl-1,3-diaminopropane 
• 75321-10-7 3-propyl tosylate 

Downstream Products

• 35980-62-2 1,5,9-triazacyclododecane trihydrobromide 
• 294-80-4 1,5,9-triazacyclododecane 

Relevant articles and documents

Syntheses, conformations, and basicities of bicyclic triamines

The multistep syntheses of several bicyclic triamines are described, all of which have an imbedded 1,5,9-triazacyclododecane ring. In 1,5,9-triazabicyclo[7.3.3]pentadecanes 12, 13, 15, and 16, two nitrogens are bridged by three carbons. The monoprotonated forms of these triamines are highly stabilized by a hydrogen-bonded network involving the bridge and both bridgehead nitrogens, producing a difference of more than 8 pKa units in acidities of their monoprotonated and diprotonated forms. The one- and zero-carbon bridges in 1,5,9-triazabicyclo[9.1.1]tridecane (23) and 7-methyl-1,5,9-triazabicyclo[5.5.0]dodecane (39) do not enhance the stabilities of their monoprotonated forms. X-ray crystal structures and computational studies of 12·HI and 16·HI reveal similar, but somewhat weaker, hydrogen-bonded networks, relative to 15·HI. The activation free energies for conformational inversion of 13·HI (14.4 ± 0.2 kcal/mol), 16·HI (15.0 ± 0.1 kcal/mol) and 16 (8.8 ± 0.3 kcal/mol) were measured by variable-temperature 1H and 13C NMR spectroscopy. These experimental barriers give an estimate of 6.2 kcal/mol for the strength of the bifurcated hydrogen bond between the bridge nitrogen and cavity proton in 16·HI. Computational studies support the hypothesis that N-inversion occurs in an open conformation, leading to an estimate of 10.32 kcal/mol for the enthalpy of the bifurcated hydrogen bond in 16·HI in the gas phase.

MACROHETEROCYCLES. 15.* SYNTHESIS OF MACROCYCLIC POLYAMINES IN A BIPHASIC SYSTEM

Macrocyclic polyamines are conveniently synthesized by condensation of bissulfonamides with ditosylates or dibromides of glycols in the biphasic system toluene(xylene)-aqueous sodium hydroxide.

MACROHETEROCYCES. XXXVI. A CONVENIENT METHOD FOR SYNTHESIS OF DI- AND POLYAZACROWN ETHERS

A method is proposed for the production of di- and polyazacrown ethers by the condensation of bissulfonamides with dibromides or ditosyloxy derivatives in a two-phase aqueous alkali-toluene (benzene) system.The optimum concentration range for the substrate and the alkylating agent is 0.017-0.1 M.The catalytic activity of the quaternary ammonium salts decreases in the order (Bu)4NI > (Bu4)NBr > (Bu4)NCl > (Bu4)NHSO4 > (C2H5)3C6H5CH2NCl >> (Et)4NI > (Et)4NBr.The highest yields of te 12-membered azacrown ethers are obtained in the presence of lithium hyroxide, and the largest yields of the crown ethers with larger ring sizes are obtained in the presence of sodium or potassium hydroxide, and this is probably due to the matrix effects of the cation.