5447-71-2

Usage

Uses

Used in Pharmaceutical Industry:
(1R,2S,5R)-5-methyl-2-(propan-2-yl)cyclohexyl 4-aminobenzoate is utilized as an anesthetic and analgesic agent for medical applications. It is commonly administered as a local anesthetic during surgical procedures to numb specific areas and prevent pain sensation. Additionally, it serves as a pain relief medication, working by blocking nerve signals in the body and providing effective analgesia.
(1R,2S,5R)-5-methyl-2-(propan-2-yl)cyclohexyl 4-aminobenzoate's unique chemical structure, including the (1R,2S,5R) configuration, is designed to enhance its binding affinity and inhibitory action on specific receptors within the nervous system, thereby contributing to its efficacy as an anesthetic and analgesic.

Upstream product

• 4277-14-9 menthol p-nitrobenzoate 
• 4277-14-9 (1R,2S,2S,5R)-2-isopropyl-5-methylcyclohexyl-1-(4'-nitrobenzoate) 
• 122-04-3 4-nitro-benzoyl chloride 
• 2216-51-5 (-)-menthol 

Relevant academic research and scientific papers

Copper-free Sandmeyer-type Reaction for the Synthesis of Sulfonyl Fluorides

A copper-free Sandmeyer-type fluorosulfonylation reaction is reported. Utilizing Na2S2O5 and Selectfluor as the sulfur dioxide and fluorine sources, respectively, aryldiazonium salts were transformed into sulfonyl fluorides. The one-pot direct synthesis of sulfonyl fluorides from aromatic amines was also realized via in situ diazotization. The practicality of this method was demonstrated by the broad functional group tolerance, gram-scale synthesis, and late-stage fluorosulfonylation of natural products and pharmaceuticals.

[Ph3C][B(C6F5)4]: A Highly Efficient Metal-Free Single-Component Initiator for the Helical-Sense-Selective Cationic Copolymerization of Chiral Aryl Isocyanides and Achiral Aryl Isocyanides

Commercially available [Ph3C][B(C6F5)4] served as a highly efficient metal-free and single-component initiator not only for the carbocationic polymerization of polar and bulky aryl isocyanides with extremely high activity up to 1.2×107 g of polymer/(molcat. h), but also for the helical-sense-selective polymerization of chiral aryl isocyanides and copolymerization with achiral aryl isocyanides to afford high-molecular-weight functional poly(aryl isocyanide)s with good solubility as well as AIE characteristics and/or a single-handed helical conformation.