54474-50-9

Usage

Uses

Used in Pharmaceutical Industry:
2,4-DIMETHYL-3-PYRROLEPROPIONIC ACID is used as a key intermediate in the synthesis of various pharmaceuticals for its potential to contribute to the development of drugs with anti-inflammatory and analgesic properties. Its role in the synthesis process is crucial for creating medications that can alleviate pain and reduce inflammation.
Used in Agrochemical Industry:
In the agrochemical sector, 2,4-DIMETHYL-3-PYRROLEPROPIONIC ACID is utilized as an intermediate in the production of agrochemicals, highlighting its versatility and importance in different chemical applications.
Used in Neurological Disorder Treatment:
2,4-DIMETHYL-3-PYRROLEPROPIONIC ACID is studied for its potential role in treating neurological disorders, given its pharmacological properties that may help in managing the symptoms and progression of such conditions.
Used as a Neuroprotective Agent:
2,4-DIMETHYL-3-PYRROLEPROPIONIC ACID is also being investigated for its neuroprotective capabilities, suggesting that it could be instrumental in safeguarding the nervous system from damage or degeneration, thereby offering therapeutic benefits in neurodegenerative diseases.

InChI:InChI=1/C9H13NO2/c1-6-5-10-7(2)8(6)3-4-9(11)12/h5,10H,3-4H2,1-2H3,(H,11,12)

Upstream product

• 54278-11-4 2,4-dimethyl-5-carboxy-1H-pyrrole-3-propanoic acid 
• 51912-00-6 4-(2-carboxy-ethyl)-3-carboxymethyl-5-methyl-pyrrole-2-carboxylic acid 
• 493-90-3 mesoporphyrin IX 
• 635-65-4 bilirubin 
• 2386-37-0 ethyl 3,5-dimethyl-4-(2-methoxycarbonyl-ethyl)pyrrole-2-carboxylate 
• 37789-64-3 4-(2-carboxyethyl)-3,5-dimethyl-1H-pyrrole-2-carboxylic acid ethyl ester 
• 53700-88-2 Ethyl 3-(ethoxycarbonyl)methyl-5-methylpyrrole-2-carboxylate 
• 6122-77-6 3-ethoxycarbonylmethyl-4-formyl-5-methyl-pyrrole-2-carboxylic acid ethyl ester 
• 74839-03-5 5-ethoxycarbonyl-4-ethoxycarbonylmethyl-2-methylpyrrole-3-carboxylic acid 
• 52887-35-1 Ethyl 4-benzyloxycarbonyl-3-ethoxycarbonylmethyl-5-methylpyrrole-2-carboxylate 
• 53700-91-7 ethyl 3-(2-ethoxycarbonylethyl)-4-ethoxycarbonylmethyl-2-methylpyrrole-5-carboxylate 
• 54278-10-3 ethyl 5-(ethoxycarbonyl)-2,4-dimethyl-1H-pyrrole-3-propanoate 
• 17266-65-8 ethyl 4,6-dioxo-5-methylheptanoate 

Downstream Products

• 114155-54-3 1-bromo-3,13-diethyl-8,18-bis(2-(methoxycarbonyl)ethyl)-2,7,12,17,19-pentamethyl-5,15-biladienium dibromide 
• 210644-62-5 (Z)-5-[(1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrol-3-propanoic acid 
• 251356-45-3 SU 16f 

Relevant academic research and scientific papers

Boradiazaindacene dyes for technology of biological microchips

A number of boradiazaindacene dyes containing a carboxyl group separated from a fluorophore by two methylene units were synthesized. The compounds have narrow spectral bands with absorption maxima at 480-530 nm and fluorescence maxima at 500-550 nm. Succinimide esters of these compounds and the corresponding fluorescent-labeled oligonucleotides were also prepared. Boradiazaindacene dyes can be used as fluorescent labels for oligonucleotides for analysis of melting curves of duplexes on microchips either by themselves or in combination with Texas Red. They can also be applied for labeling primers for polymerase chain reaction.

5-sulfonamido-substituted indolinone compounds as protein kinase inhibitors

The present invention relates to 5-sulfonamido substituted indolinones that modulate the activity of protein kinases (“PKs”). The compounds of this invention are therefore useful in treating disorders related to abnormal PK activity. Pharmaceutical compositions comprising these compounds, methods of treating diseases utilizing pharmaceutical compositions comprising these compounds and methods of preparing them are also disclosed.

Sulfonamide substituted indolinones as inhibitors of DNA dependent protein kinase (DNA-PK)

The present invention relates generally to the field of radiosensitizing agents which are capable of enhancing radiotherapy by inhibiting DNA-PK (DNA-protein kinase). In particular, it relates to sulfonamide substituted indolinones which inhibit DNA-PK.

Pyrrole substituted 2-indolinone protein kinase inhibitors

The present invention relates to novel pyrrole substituted 2-indolinone compounds and physiologically acceptable salts and prodrugs thereof which modulate the activity of protein kinases and therefore are expected to be useful in the prevention and treatment of protein kinase related cellular disorders such as cancer.

Bromination of Dipyrromethenes for Porphyrin Synthesis

5'-Bromo-5-(bromomethyl)-2,2'-dipyrromethenium bromides (1) and dimers were prepared in 90percent yield from 5'-unsubstituted (16), 5'-carboxy- (15),or 5'-bromo-5-methyl-2,2'-dipyrromethenium bromides (17) by treatment of the latter with bromine and trifluoroacetic acid in chlorocarbon solvents at room temperature.Dipyrromethenes (1) are important intermediates in the Johnson regioselective synthesis of porphyrins via biladienes (3).Improvements in porphyrin synthetic methodology are exemplified by the preparation of etioporphyrin III (4a) and mesoporphyrin II dimethyl ester (4b)