545-28-8 Usage
Chemical structure
A naturally occurring bufadienolide compound with a unique molecular structure.
Source
Found in the skin of toads and certain plants.
Pharmaceutical properties
Investigated for its cytotoxic and anti-tumor effects, as well as its potential use as a cardiac glycoside in the treatment of heart conditions.
Biological activities
Has shown promising results in research and study, indicating potential therapeutic applications.
Development
Has the potential to be developed into therapeutic agents for various medical conditions.
Research status
Further research is needed to fully understand its mechanisms of action and potential applications.
Safety
Due to its cytotoxic properties, caution must be exercised when handling and studying this compound.
Applications
Potential use in the treatment of cancer, heart conditions, and other medical conditions, pending further research and development.
Molecular weight
Approximately 416.5 g/mol (based on the chemical formula).
Solubility
Information on solubility is not provided in the material, but bufadienolides are generally known to be more soluble in organic solvents.
Stability
Stability information is not provided in the material, but bufadienolides are generally sensitive to light, heat, and acidic or basic conditions.
Toxicity
As a cytotoxic compound, 14-Hydroxy-3-oxobufa-4,20,22-trienolide can be harmful or fatal if ingested, inhaled, or absorbed through the skin.
Legal status
The legal status of 14-Hydroxy-3-oxobufa-4,20,22-trienolide may vary by country, but it is generally not regulated as a controlled substance.
Environmental impact
Information on the environmental impact of 14-Hydroxy-3-oxobufa-4,20,22-trienolide is not provided in the material, but it is important to consider the potential ecological effects of any compound used in pharmaceutical development.
Check Digit Verification of cas no
The CAS Registry Mumber 545-28-8 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 5,4 and 5 respectively; the second part has 2 digits, 2 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 545-28:
(5*5)+(4*4)+(3*5)+(2*2)+(1*8)=68
68 % 10 = 8
So 545-28-8 is a valid CAS Registry Number.
545-28-8Relevant articles and documents
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Meyer
, p. 1593,1597 (1949)
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Modulators of Hypoxia Inducible Factor-1 and Related Uses
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Page/Page column 28; 30, (2009/02/11)
The invention features compounds of formulas I or II: and pharmaceutically acceptable salts and prodrugs thereof, as well methods for modulating the effects of local and systemic hypoxic events using the compounds.
Potential radiodrugs for adrenal gland scintigraphy, I: Radioiodination of tyramine derivatives of some digitalis aglycones and scillarenin
Roder,Lutz
, p. 837 - 842 (2007/10/02)
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