54503-21-8Relevant academic research and scientific papers
An efficient new enzymatic method for the preparation of β-aryl-β-amino acid enantiomers
Tasnadi, Gabor,Forro, Eniko,Fueloep, Ferenc
, p. 2072 - 2077 (2008/12/22)
An efficient synthesis of β-aryl-β-amino acid enantiomers has been developed via the lipase-catalysed enantioselective hydrolysis of the corresponding racemic ethyl esters in an organic solvent. High enantioselectivities (E >100) were observed when the lipase PS-catalysed reactions were performed with H2O (0.5 equiv) in diisopropyl ether at 45 °C. The products could be easily separated and were obtained in good yields of ≥40%.
Cyclic amides
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, (2008/06/13)
Cyclic amides are inhibitors of tumor necrosis factor and can be used to combat cachexia, endotoxic shock, and retrovirus replication. A typical embodiment is 3-phenyl-3-(1-oxoisoindolin-2-yl)propionamide.
