54513-99-4Relevant academic research and scientific papers
Synthesis of - and Lysines
Tsuzuki, Hirohisa,Mashimo, Takuya,Mukumoto, Mamoru,Mataka, Shuntaro,Udagawa, Jun,Tashiro, Masashi
, p. 2346 - 2360 (2007/10/03)
Starting from readily available cyclohexanone (1), synthesis of the title - and lysines (11) and (18) is described.Although direct incorporation of an amino or phthalimide group into the 2-bromohexanoic acid (5), which was derived from 1 in five steps. leading to 11 was unsuccessful due to hydrogen-deuterium scrambling, compound (11) was obtained in 86percent deuterium content via incorporation of an azido group and subsequent hydrogenation.Furthermore, compound (18) having 99percent deuterium content could be prepared by acid-catalysed deuterium exchange of 1 as a key-step.
Hydrogen Transfer Reactions, 19. - The Catalysis of Hydrogen Transfer and 1,5-H Shift by Rhodium(III) Chloride in Homogeneous Organic Systems
Wehage, Hubert,Heesing, Albert
, p. 209 - 215 (2007/10/02)
In homogeneous solution, partly in the presence of a phase-transfer catalyst, rhodium(III) chloride catalyzes the disproportionation of 1,3-cyclohexadiene and to a lesser extent 1,5-H shifts.In the start phase the catalyst is reduced to the active monovalent state.In these catalytic systems the dehydrogenation proceeds stereoselectively. - This was shown by tracer experiments and isotopes effects using deuterated 1,3-cyclohexadienes 1a-d, which were synthesized with high isotopomeric purity.Key Words: Rhodium chloride / Hydrogen transfer / Deuterated 1,3-cyclohexadienes / Isotope effects
