54517-97-4Relevant academic research and scientific papers
Solid phase chemistry approach to the SAR development of a novel class of active site-directed thrombin inhibitors
Johnson, Mary George,Bronson, Duane D.,Gillespie, Jan E.,Gifford-Moore, Donetta S.,Kalter, Kyomi,Lynch, Michael P.,McCowan, Jefferson R.,Redick, Catherine C.,Sall, Daniel J.,Smith, Gerald F.,Foglesong, Robert J.
, p. 11641 - 11652 (2007/10/03)
A solid phase chemistry approach utilizing Mitsunobu chemistry, amine functionalization, and parallel purification was used to produce a diverse library of benzothiophene analogs. These analogs were used to advance the SAR of this class of molecules and give new directions for future studies.
