54520-41-1Relevant academic research and scientific papers
Alkylative Amination of Non-enolizable Aldehydes with Alkyl(dialkylamino)titanium Derivatives
Seebach, Dieter,Schiess, Martin
, p. 2598 - 2602 (1982)
The readily available tris(diethylamino)methyltitanium and related compounds (see 1 in Scheme 2) react with non-enolizable aldehydes to give tertiary amines 2; these amines result from direct replacement of the carbonyl O-atom by an alkyl and an amino group (Scheme 3).A tentative mechanism is proposed, according to which the amino group is transferred to the carbonyl C-atom prior to the alkyl group (Scheme 4).
